保健・化学物質対策

6th International Symposium on Environmental Endocrine Disrupters 2003

Abstracts

Program and Speakers

Program open to the public

Program for Experts

Leaflet

Date: December 3 (Wed.) - 5 (Fri.), 2003
Venue: Sendai International Center
　　　　Aobayama, Aoba-ku, Sendai, Miyagi 980-0856, JAPAN

Organizer: Ministry of the Environment, Government of Japan

Support: Miyagi Prefecture, City of Sendai

Cooperation: Japan Society of Endocrine Disrupter Research

Objectives: The objective of the symposium is to have the foremost researchers in and outside of Japan gather and discuss primarily the following three issues concerning endocrine disrupters (EDs):

  1. to share information on the initiatives being taken by various countries of the world in dealing with ED-related issues;
  2. to discuss the direction of future research on EDs through international cooperation; and
  3. to exchange wide-ranging opinions on chemicals in the environment as an issue of both local and global significance

Contact Office/Registration:

Please contact Secretariat for International Symposium on Environmental Endocrine Disrupters 2003.
Kosai Kaikan Bldg. 6F, 5-1 Kojimachi, Chiyoda-ku, 102-8481 Tokyo, Japan
Tel: +81-3-3263-5394 / Fax: +81-3-5216-3115
Email:eed03@congre.co.jp

Program:

Wednesday, December 3, 2003 (Program Open to the Public)

13:30-13:40　Opening Remarks

Greetings by the Organizer and Guests

13:40-14:40　Special Lecture [PDF]

Under the theme of the effect of endocrine disrupters on wildlife, the lecture will be given by Dr. Glen Van Der Kraak, Professor of University of Guelph in Canada, who participated in the preparation of WHO's Global Assessment of the State-of-the-Science of Endocrine Disrupters.

Current Status of Endocrine Disruption in Wildlife
　Glen Van Der Kraak(University of Guelph, Canada)

14:40-16:30　Initiatives up to the Present [PDF]

This part provides an introduction to initiative and current state of the issue of endocrine disrupters from the standpoint of government, researchers, industry and educators. It also includes questions from the audience.

Moderator:
　Tsuguyoshi Suzuki (Emeritus Professor, University of Tokyo, President, Japan Society of Endocrine Disrupter Research, Japan)

Current Strategies against Environmental Endocrine Disrupters by the Ministry of the Environment, Government of Japan 　Kazuhiko Adachi (Ministry of the Environment, Government of Japan)
Development of Various Screening Methods of Endocrine Disrupting Chemicals
　Taisen Iguchi (Okazaki National Research Institutes, Japan)
Measures Taken by the Chemical Industry regarding Endocrine Disrupters
　Kimihiro Iwamoto (Mitsui Chemicals Inc., Japan)
Perspectives on Chemical Substances Fostered via Environmental Education -Through Inquiry Based Global Environmental Education Programe-
　Yukihiko Oikawa (Kesennuma Omose Elementary School, Japan)

<Questions and Answers Session>
　Kazuhiko Adachi (Ministry of the Environment, Government of Japan)
　Taisen Iguchi (Okazaki National Research Institutes, Japan)
　Kimihiro Iwamoto (Mitsui Chemicals Inc., Japan)
　Yukihiko Oikawa (Kesennuma Omose Elementary School, Japan)
　Tim Meredith (WHO)

16:30-16:50　Break

16:50-18:00　Panel Discussion [PDF]

The Role of Politics in Endocrine Disruptor Issues

Politicians discuss their views concerning how politics has involved in the issue of endocrine disrupters and what will be expected of government in the future.

Moderator:
　Kenji Manabe (Member of the House of Councilors, Japan)
　Masatoshi Morita (National Institute for Environmental Studies, Japan)

Panelists:
　Jiro Aichi (Member of the House of Councilors, Japan)
　Shuichi Kato (Member of the House of Councilors, Senior Vice-Minister of the Environment, Japan)
　Hajimu Fujii (Mayor of Sndai City, Japan)

Thursday, December 4, 2003 (Program for Experts)

9:30-11:30　Session 1 Overseas Initiatives [PDF]

This session provides an introduction of current status and initiatives concerning endocrine disrupters overseas.

Moderator: Terri Damstra (WHO)

European Community Initiatives in Drafting Policies and Supporting Research in the Endocrine Disrupter Field
Ragnor Pedersen (University of London School of Pharmacy, UK)

USEPA's Endocrine Disruptors Programs: Regulatory and Researh
　Elaine Z. Francis (EPA, USA)
The Current OECD Initiative on Endocrine Disrupters Testing and Assessment (EDTA)
　Anne Gourmelon (OECD)
WHO/IPCS Initiatives on Endocrine-Disrupting Chemicals
　Tim Meredith (WHO)

11:30-13:00　Lunch

13:00-15:30　Session 2 Basic Science [PDF]

Endocrine disrupters are suspected of having effects on the development process of animals in various ways. This session takes up the reproductive system, brain and thyroid hormon and provides an introduction to the latest research and future prospects concerning the molecular mechanism of the hormone action and basic control mechanism of development and differentiation for these tissues and organs.

Chairperson: Yoshitaka Nagahama (Okazaki National Research Institutes, Japan)

Sex Determination and Differentiation in Vertebrates: A Target for Endocrine Disrupting Chemicals
　Yoshitaka Nagahama (Okazaki National Research Institutes, Japan)
Cross-talk of Estrogen receptor- and AhR-mediated signalings
　Shigeaki Kato (University of Tokyo, Japan)
Chemical Interference with Non-genomic Steroid Actions: A Novel Mechanism of Endocrine Disrupters
　Peter Thomas (University of Texas, USA)
Hormonal Regulation of Oocyte Maturation in Starfish
　Masatoshi Mita (Teikyo University, Japan)
Epigenetic Transgenerational Endocrine Disruptor Effects on Male Fertility
　Michael K. Skinner (Washington State University, USA)

15:30-15:45　Break

15:45-18:15　Session 3 Wildlife [PDF]

This session deals with the latest research initiatives concerning the effects of chemical substances on various animals such as invertebrates, fish and birds, and the current effects on wildlife reported in the field and how recovery from such effects is going.

Chairperson: Taisen Iguchi (Okazaki National Research Institutes, Japan)

Current Status of Contamination by Organotin Compounds and Imposex in Gastropods from Japan and Possible Physiological/Biochemical Mechanism of Organotin-Induced Imposex in Gastropods
　Toshihiro Horiguchi (National Institute for Environmental Studies, Japan)
Endocrine Disruption in Wildlife of the Great Lakes of North America, Past and Present
　Glen A. Fox (Canadian Wildlife Service of Environment, Canada) Aquatic Species in Ecosystems at Risk: Assessing Normal and Abnormal Endocrine Responses in Wildlife
　Louis J. Guillette Jr. (University of Florida, USA)
Testing Strategy for Addressing the Effects of Endocrine Disrupters on Invertebrates
　Jose V. Tarazona (Spanish National Institute for Agricultural and Food Research and Technology (INIA), Spain)
Effluent Induced Disruption of Sexual Function in Roach (Rutilus rutilus) in Rivers in the United Kingdom - A Case History and Future Perspectives
　Charles R. Tyler (University of Exeter, UK)

18:15-19:30　Break

19:30-21:30　Session 4 Exposure [PDF]

The purpose of this session is an introduction to accurate methods of measuring the degree of exposure of people and wildlife to endocrine disrupters, which is important for assessing risk of chemicals suspected of having endocrine disrupting effects.

Chairperson: Masatoshi Morita (National Institute for Environmental Studies, Japan)

Studies on EDC Exposure in Malaysian Population
　Mustafa Ali Mohd (University of Malaya, Malaysia)
Current Situation of Human Fetal Exposure to Multiple Chemicals in Japan
　Hideki Fukata
Mechanistic Biomarkers and Adverse Effect Endpoints in Fish Reproductive Toxicity Testing: Practical Reccomendations for addressing the Risk of Aquatic Exposure
　Thomas H. Hutchinson (AstraZeneca Global Safety, UK)
GIS-based Environmental Fate Model and the Exposure Assessment of Endocrine Disrupting Chemicals
　Noriyuki Suzuki (National Institute for Environmental Studies, Japan)

Friday, December 5, 2003 (Program for Experts)

9:00-11:30　Session 5 Human Health [PDF]

This session focuses on the latest findings concerning the effect of chemical substances in the environment on human beings, and research on ways to assess environmental risk for children and fetuses in order to prevent the harmful effects of such chemicals.

Chairperson: Chisato Mori (Graduate School of Medicine, Chiba University, Japan)

Semen Quality in Relation to Exposure to Currently Used Pesticides
　Shanna Swan (University of Missouri, USA)
A Focus on Children's Environmental Health
　Richard A. Becker (American Chemistry Council, USA)
Polybrominated Diphenylethers (PBDEs) and Endocrine Disruption
　Joseph G. Vos (National Institute of Public Health and the Environment, Netherlands)
The Developmental Basis of Disease: Role of Endocrine Disrupting Chemicals
　Jerrold J. Heindel (National Institute of Environmental Health Sciences, USA)
Fetal Exposure to Multiple Chemicals: Necessity to Develop a New Risk Assessment and Risk Reduction Method Based on Human Fetus
　Chisato Mori (Graduate School of Medicine, Chiba University, Japan)

11:30-13:00　Lunch

13:00-14:40　Session 6 Causal Criteria for Assessing Endocrine Disrupters [PDF]

Phenomena thought to be related to endocrine disruption have been reported throughout the world. Principal examples will be provided by guest speakers. Elements required for assessment will be discussed in the form of case studies.

Chairperson:
　Tohru Inoue (National Institute of Health Sciences, Japan)
　Robert J. Kavlock ((EPA, USA)

<Opening Session>
　Robert J. Kavlock (EPA, USA)
　Tohru Inoue (National Institute of Health Sciences, Japan)

<Overview>
Causal Criteria for Assessing Endocrine Disruptors
　Terri Damstra (WHO)
<Human>
Human Cancer Epidemiology (e.g., breast cancer)
　Lizbeth Lopez-Carrillo (Mexico National Institute of Public Health, Mexico)
Human Developmental Neurotoxicity (PCBs)
Gerhard Winneke (Medical Institute of Environmental Hygiene at Heinrich-Heine-Universitat Dusseldorf, Germany)

<Discussion>
Commentators:
　Elaine Z. Francis(EPA, USA)
　Mikio Momoeda (University of Tokyo, Japan)
　Chisato Mori (Graduate School of Medicine, Chiba University, Japan)
　Noriyuki Koibuchi (Graduate School of Medicine, Gunma University, Japan)

14:40-15:00　Break

15:00-16:30　Wildlife [PDF]

Exposure to Wildlife
　Masatoshi Morita (National Institute for Environmental Studies, Japan)
Ecotoxicological Risk Assessment of Atrazine in Amphibians
　Glen Van Der Kraak (University of Guelph, Canada)

<Discussion>
Commentators:
　George Daston (Miami Valley Laboratories, USA)
　Charles R. Tyler (University of Exeter, UK)
　Koji Arizono (Kumamoto University, Japan)
　Taisen Iguchi (Okazaki National Research Institutes, Japan)

<Questions and Answers Session>
　Robert J. Kavlock (EPA, USA)
<Closing Remarks>
　Tohru Inoue (National Institute of Health Sciences, Japan)