保健・化学物質対策

International Symposium on Environmental Endocrine Disrupters 2001

Tsukuba International Congress Center
December 15-17, 2001

Abstracts

Program and Speakers

Sessions open to the public

Expert Sessions

Programs and Presentation Topics:

December 15　Sessions open to the public (afternoon only)

Welcome Address

Yoriko Kawaguchi (Minister of the Environment)
Masaru Hashimoto (Governor, Ibaraki Prefectural Government)
Hiroshi Hase (Member of the House of Representatives)
Shuichi Kato (Member of the House of Councilors)

Special Lecture

Abstract of Special Lecture [PDF]

POPs - Persistent Organic Pollutants
　Bo Jansson (Stockholm University, Sweden)

Part 1 Current Strategy in Japan

Abstracts of Current Strategy in Japan [PDF]

Current Strategies against Environmental Endocrine Disrupters by the Ministry of the Environment, Government of Japan
　Kazuhiko Adachi (Ministry of the Environment, Government of Japan)
Efforts and Strategies to Deal with the Issue of Endocrine Disruptors in Japan　Results of a Nationwide Survey by the Ministry of the Environment
　Shinsuke Tanabe (Center for Marine Environmental Studies, Ehime University, Japan)
Present Status of Human Fetal Exposure to Several Endocrine Disruptors in Japan
　Chisato Mori (Graduate School of Medicine, Chiba University, Japan)
Testing System for Hazard Assessment of Endocrine Disruptors in Fish
　Hirofumi Yokota (Chemicals Evaluation and Research Institute (CERI), Japan)
An Approach for Evaluating Low-dose Effects of Suspected Endocrine Disruptors
　Hiroaki Aoyama (Institute of Environmental Toxicology, Japan)
Development of a Test Method for Risk Assessment of Endocrine Disrupting Chemicals Using DNA　Microarray Technology
　Akihiro Kondo (Biotechnology Research Laboratory, Takara Shuzo Co., Ltd., Japan)
UK-J Research Project for the Endocrine Disrupters in the Aquatic Environment
　Koji Arizono (Prefectural University of Kumamoto, Japan)
Endocrine Disrupters Research in National Institute for Environmental Studies
　Masatoshi Morita (National Institute for Environmental Studies (NIES), Japan)

Part 2 Panel Discussion - Environmental Hormones in the 21st Century - Searching for Widely Applicable Approaches -

Abstracts of Panel Discussion [PDF]

Panelists:
　Kazuyuki Aihara (Graduate School of Frontier Sciences, University of Tokyo, Japan)
　Yoshino Oishi (Photo Journalist)
　Ichiro Kono (University of Tsukuba, Japan)
　Chisato Mori (Graduate School of Medicine, Chiba University, Japan)
　Takeshi Yoro (Kitasato University, Japan)
　John Peterson Myers (W. Alton Jones Foundation, U.S.A.)
　Soichiro Iwao (Ministry of the Environment, Government of Japan)

Moderator:
　Masashi Yatabe (Japan Broadcasting Corporation (NHK), Japan)

December 16　Expert Sessons

Session 1 - Effects on the Brain and Behavioral Development

Abstracts of Session 1 - Effects on the Brain and Behavioral Development [PDF]

Chairperson:
　Yoichiro Kuroda (Tokyo Metropolitan Institute for Neuroscience, Japan)

Brain Development and Behavior as a Toxic Target of Dioxin and Other Environmental Chemicals
　Bernard Weiss (University of Rochester School of Medicine and Dentistry, U.S.A.)
Commentator:
　Chiharu Tohyama (National Institute for Environmental Studies (NIES), Japan)
Thyroid Hormone, Brain Development, and the Environment
　R. Thomas Zoeller (University of Massachusetts, U.S.A.)
Commentator:
　Noriyuki Koibuchi (Gunma University School of Medicine, Japan)
Functional Development of Neuronal Networks in Culture - An in vitro Assay System of Developing Brain for Endocrine Disruptors
　Yoichiro Kuroda (Tokyo Metropolitan Institute for Neuroscience, Japan)
Risk Analysis of Endocrine Disrupting Chemicals Using Higher Animals
　Yasuhiro Yoshikawa (Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan)
Evidence for the Role of Environmental Neurotoxicants in Learning and Behavioral Disabilities
　Deborah C. Rice (U.S. Environmental Protection Agency (EPA), U.S.A.)

Session 2 - Screening and Testing Methodology

Abstracts of Session 2 - Screening and Testing Methodology [PDF]

Chairperson:
　Herman B.W.M. Koeter (OECD)

International Initiatives to Develop a Global Strategy on Endocrine Disruptors Testing and Assessment
　Herman B.W.M. Koeter (OECD)
International Harmonization of a Screening and Testing Framework for Estrogenic Chemicals
　James W. Owens (Procter & Gamble, U.S.A.)
Testing Strategies for Endocrine Disruption in the Aquatic Environment
　Daniel B. Pickford (AstraZeneca Global Safety Health and Environment, U.K.)
Screening and Testing of Endocrine Disruptors in Avian Species
　Masaru Wada (Tokyo Medical and Dental University, Japan)
Recent Research of Endocrine Disrupters Testing of Amphibians in Japan
　Minoru Uchiyama (Toyama University, Japan)

Session 3 - High Throughput Pre-Screening (HTPS) and Quantitative Structure-Activity Relationship (QSAR) Techniques

Abstracts of Session 3 - High Throughput Pre-Screening (HTPS) and Quantitative Structure-Activity Relationship (QSAR) Techniques [PDF]

Chairpersons:
　Jun Kanno (National Institute of Health Sciences, Japan)
　Robert J. Kavlock (U.S. Environmental Protection Agency (EPA), U.S.A.)

HTPS and QSAR:　Screening Methods and Cutting Edge Sciences in Endocrine Disruptor Issue
　Jun Kanno (National Institute of Health Sciences, Japan)
Priority Setting of Endocrine Disruptors Using QSARs
　Weida Tong (FDA's National Center for Toxicological Research (NCTR), U.S.A.)
3D-SAR Analysis of EDs Based on Target Receptor Structure
　Nobuo Tomioka, Akiko Itai (Institute of Medicinal Molecular Design, Inc., Japan)
Efficacy of Highthroughput Pre-Screening Procedure Based on Reporter Gene Assay
　Masahiro Takeyoshi (Chemicals Evaluation and Research Institute (CERI), Japan)
A New Approach to Functional Genomics
　Bruce Blumberg (University of California, U.S.A.)
Combinatorial Phage Library Screening for Estrogen Receptor Interacting Peptides: A Tool for Studying Xenoestrogen Biology and Pharmacology
　Julianne M. Hall (National Institute of Environmental Health Sciences, U.S.A.)

Night Session - Toxico-Genomics

Abstracts of Night Session - Toxico-Genomics [PDF]

Chairperson:
　Tohru Inoue (National Institute of Health Sciences, Japan)

Functional Genomics Towards Understanding of the Mechanisms of Life
　Yuji Kohara (National Institute of Genetics, Japan)
Toxicogenomics and Its Potential for Assessment of Pollutant Impact in Fish
　Tim Williams (The University of Birmingham, U.K.)
Progress in Medaka Genomics
　Kiyoshi Naruse (Graduate School of Science, University of Tokyo, Japan)
Status of Xenopus laevis and Xenopus tropicalis microarrays
　Bruce Blumberg (University of California, U.S.A.)
Toxicogenomic Assessment of Endocrine Disruptors
　Timothy Richard Zacharewski (Michigan State University, U.S.A.)
Molecular Profiling of Genes Showing Altered Expression in the Livers of Rats Treated with Non-Genotoxic Carcinogens for 28 Days
　Makoto Shibutani (National Institute of Health Sciences, Japan)
Fetal Transcript Profiles for Endocrine Disrupters
　George P. Daston (The Procter & Gamble Company, U.S.A.)

December 17　Expert Sessions

Session 4 - Effects on Wildlife

Abstracts of Session 4 - Effects on Wildlife [PDF]

Chairperson:
　Taisen Iguchi (Okazaki National Research Institutes, Japan)

The Significance of Interactions Between Endocrine Disruption and Other Mechanisms of Toxicity
　Michael H. Depledge (Plymouth Environmental Research Centre, University of Plymouth, U.K.)
Endocrine Disruptor Susceptibility Genes: Molecular Analysis of Aryl Hydrocarbon Receptors and Dioxin Sensitivity in Wildlife
　Mark E. Hahn (Woods Hole Oceanographic Institution, U.S.A.)
The Effects of Endocrine Disruptors on Fish Maturation and Reproduction -A Focus on Projects Underway at the Ministry of Agriculture, Forestry, and Fisheries-
　Kazunori Fujii (National Research Institute of Fisheries and Environment of Inland Sea, Fisheries Research Agency, Japan)
Atrazine Produces Hermaphrodites in Frogs: Connecting Laboratory and Field Studies
　Tyrone B. Hayes (University of California, Berkeley, U.S.A.)
Beyond Estrogens -Multiple Mechanisms of Endocrine Disruption
　Louis J. Guillette, Jr. (University of Florida, U.S.A.)

Session 5 - Effects on Health

Abstracts of Session 5 - Effects on Health [PDF]

Chairpersons:
　Fumiki Hirahara (Yokohama City University School of Medicine, Japan)
　Paul A.L. Lancaster (University of New South Wales, Australia)

Birth Defects Monitoring in Japan -Possible Effects of Environmental Endocrine Disruptors-
　Fumiki Hirahara (Yokohama City University School of Medicine, Japan)
Cryptorchidism and Hypospadias in The Netherlands: Are Endocrine Disrupters Involved?
　Frank H. Pierik (Erasmus University Rotterdam, The Netherlands)
Trends in Male Reproductive Health
　Paul A.L. Lancaster (University of New South Wales, Australia)
1,1-Dichloro-2,2-Bis (P-Chlorophenyl) Ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five US Studies
　David J. Hunter (Harvard Medical School and School of Public Health, U.S.A.)

Session 6 - Reports on Overseas Activities

Abstracts of Session 6 Reports on Overseas Activities [PDF]

Chairperson:
　Teiji Takei (Ministry of the Environment, Government of Japan)

Keynote Presentation: The WHO/UNEP/ILO International Programme on Chemical Safety (IPCS) Global Assessment of the State-of-the-Science of Endocrine Disrupting Chemicals (EDCs)
　Robert J. Kavlock (U.S. Environmental Protection Agency (EPA), U.S.A.)
Progress in Implementing the Endocrine Disruptor Screening Program
　Gary E. Timm (U.S. Environmental Protection Agency (EPA), U.S.A.)
Chemistry Industry's Research Program on Hormonally Active Agents (HAAs)
　Judith A. Graham (American Chemistry Council, U.S.A.)
Research on Endocrine Disruption in the UK
　Kathleen Cameron (DEFRA, U.K.)
Endocrine Disruptors Research in Malaysia
　Mustafa Ali Mohd (University of Malaya, Malaysia)