保健・化学物質対策

International Symposium on Environmental Endocrine Disrupters 2000

Pacifico Yokohama
December 16-18, 2000

Abstracts

Program and Speakers

Sessions open to the public

Expert Sessions

Programs and Presentation Topics

December 16 Sessions open to the public (afternoon only)

Welcome Address

Yoriko Kawaguchi (Minister of State, Director-General of the Environment Agency)
Hiroshi Okazaki (Governor, Kanagawa Prefectural Government)

Special Lecture

Abstract of Special Lecture [PDF]

Endocrine Disruption Testing: Toward a Better Understanding of Inner Space
　Theo COLBORN (Senior Scientist and Program Director, World Wildlife Fund

Part 1 Current Strategy

Abstracts of Current Strategy in Japan [PDF]

How the Liberal Democratic Party Takes Measures for the Problem of Chemical Substances and Future Issues
　Hiroshi HASE (Member of the House of Representatives, Japan)
How New Komeito Takes Measures for the Problem of Endocrine Disrupters (3)
　Shuichi KATO (Member of the House of Councilors, Japan)
Current Strategy on Endocrine Disruptors in the U.S.A.
　Gary E. TIMM (Environmental Protection Agency (EPA), U.S.A.)
European Community Strategy for Endocrine Disrupters
　Birgit VAN TONGELEN (European Commission, E.U.)
Government Policies Related to Endocrine Disrupters in Korea
　Geum-Su SEOG (Ministry of Environment, Republic of Korea)
Development of a Test Method for Risk Assessment of Endocrine Disrupting Chemicals Using DNA Microarray Technology
　Akihiro Kondo (Biotechnology Research Laboratory, Takara Shuzo Co., Ltd., Japan)
Current Strategies against Environmental Endocrine Disrupters by Environment Agency, Government of Japan
　Hirozo UEDA (Environment Agency, Government of Japan)

Part 2 Panel Discussion - "What Have We Foundabout Environmental Endocrine Disrupters?"

Abstracts of Panel Discussion [PDF]

Panelists:
　Theo COLBORN (Senior Scientist and Program Director, World Wildlife Fund)
　Shinsuke TANABE (Center for Marine Environmental Studies (CMES), Ehime University, Japan)
　John A. McLACHLAN (Tulane and Xavier Universities,U.S.A.)
　Osamu TSUTSUMI (University of Tokyo, Japan)
　Angelina Joy Serio DUGGAN (American Crop Protection Association, U.S.A.)
　Jun SEKIZAWA (National Institute of Health Sciences, Division of Chemo-Bio Informatics, Japan)

Moderator:
　Noboru TAKASUGI (The Chair, Yokohama City Board of Education, Japan)

December 17　Expert Sessons

Session 1 - Effects on Wildlife

Abstracts of Session 1 - Effects on the Brain and Behavioral Development [PDF]

Chairpersons:
　Taisen IGUCHI (Center for Integrative Bioscience, Okazaki National Research Institutes, Japan)
　Louis J. GUILLETTE Jr. (University of Florida, U.S.A.)

Endocrine Disrupting Contaminants: Lessons from Wildlife
　Louis J. GUILLETTE Jr. (University of Florida, U.S.A.)
Endocrine Disruption in Mollusks: Case Studies on the Rock Shell, the Ivory Shell and the Giant Abalone, Linking with Organotin Contamination in Korea and Japan
　Hyeon-Seo CHO (Yosu National University, Korea)
The Occurrence of Intersex in a Japanese Freshwater Crab<br> 　Koji ARIZONO (Prefectural University of Kumamoto, Japan)
Sexual Disruption of Wild Fish in U.K. Rivers.....What Does It All Mean?
　Susan JOBLING (Brunel University, U.K.)
Detection of Thyroid Hormone Disrupting Effects Using Frogs and a Molecular Toolbox
　Caren Christiane HELBING (University of Victoria, Canada)
Use of Chemistry and Biology to Assess Endocrine Disruptors in the Environment
　John P. GIESY (Michigan State University, U.S.A.)
Review of Present Knowledge Concerning Endocrine Disrupters and Wildlife
　Peter MATTHIESSEN (Centre for Environment, Fisheries and Aquaculture Science (CEFAS), U.K.)

Session 2 - Potential Effects on Human Health

Abstracts of Session 2 - Potential Effects on Human Health [PDF]

Chairperson:
　Yoshimasa SHISHIBA (Toranomon Hospital, Japan)

Epidemiologic Evidence for Endocirine Disruption: Studies in North Carolina, U.S.A. and Mexico
　Walter J. ROGAN (National Institute of Environmental Health Sciences (NIEHS), U.S.A.)
Environmental Exposure to Polychlorinated Biphenyls (PCBs) and Dioxins. Consequences for Lactation Performances and Long Term Brain Development of the Child. A Review of the Longitudinal Dutch PCB/dioxin Study 1 2 3 4 .
　Ernst Rudolf BOERSMA (University Hospital Groningen, the Netherlands)
Thyroid Status, Frequency of Selected Autoantibodies and Biomarkers in the Population Exposed to PCB and Other Organochlorines
　Pavel LANGER (Slovak Academy of Sciences, Slovakia)
Evidence of Endocrine Disruption in Yucheng People Exposed Polychlorinated Biphenyls and Dibenzodioxins
　Yue-Liang Leon GUO (National Cheng Kung University Medical College, Taiwan)
Dioxin and Human Health: 20 Years of Data from "Seveso", Italy
　Paolo MOCARELLI (University Milano-Bicocca, Hospital of Desio-Milano, Italy)

Session 3 - Testing Methodology

Abstracts of Session 3 -Testing Methodology [PDF]

Chairpersons:
　Masatoshi MATSUO (Sumitomo Chemical Co., Ltd., Japan)
　Thomas H. HUTCHINSON (AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, U.K.)

Ecotoxicology Test Methods for Endocrine Disrupters and Ecological Risk Assessment
　Thomas H. HUTCHINSON (AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, U.K.)
A Comparison of the Reproduction and Full Life-Cycle Tests with Medaka for Hazard Evaluation of Endocrine Disruptors
　Hirofumi YOKOTA (Chemicals Evaluation and Research Institute (CERI), Japan)
Screening of Estrogenic Chemicals Using Uterotrophic Assay
　Jun KANNO (National Institute of Health Sciences, Japan)
Screening Strategies for Androgen Active Compounds
　Paul Matthew David FOSTER (Chemical Industry Institute of Toxicology (CIIT), U.S.A.)
Tier 2 Testing for Endocrine Active Chemicals: Is the Current Multigeneration Study Design Adequate?
　Paul Matthew David FOSTER (Chemical Industry Institute of Toxicology (CIIT), U.S.A.)

December 18 　Expert Sessions

Session 4 - Mechanisms of Action

Abstracts of Session 4 - Mechanisms of Action [PDF]

Chairpersons:
　Yoshitaka NAGAHAMA (National Institute for Basic Biology, Japan)
　Hajime NAWATA (Graduate School of Medical Sciences, Kyushu University, Japan)

Gonadal Sex Differentiation in Fish and the Effects of Environment Endocrine Disrupters
　Masaru NAKAMURA (University of The Ryukyus, Tropical Biosphere Research Center, Japan)
Transcription Factors supporting Gonad Sex Differentiation
　Ken-ichirou MOROHASHI (National Institute for Basic Biology, Japan)
The Effects of Endocrine Disruptors on Steroidogenesis and StAR Protein
　Douglas Michael STOCCO (Texas Tech University Health Sciences Center, U.S.A.)
Transcription Factors and Cofactors with Endocrine Disruptors
　Hajime NAWATA (Graduate School of Medical Sciences, Kyushu University, Japan)
Endocrine Disrupter Action and Toxicology: Studies in ER Knock-Out Mice
　Kenneth S. KORACH (National Institute of Environmental Health Sciences (NIEHS), U.S.A.)

Session 5 - Low Dose Issue in the ED Reaction

Abstracts of Session 5 - Low Dose Issue in the ED Reaction [PDF]

Chairpersons:
　Tohru INOUE (Biological Safety Research Center, National Institute of Health Sciences, Japan)
　Robert J. KAVLOCK (Environmental Protection　Agency (EPA), U.S.A.)

On Low Dose Issues in the ED Reaction
　Robert J. KAVLOCK (Environmental Protection Agency (EPA), U.S.A.)
Summary of the NTP/NIEHS Endocrine Disruptors Low-Dose Peer Review
　Ronald L. MELNICK (National Institute of Environmental Health Sciences (NIEHS), U.S.A.)
Three-Generation Reproductive Toxicity Study of Bisphenol A (BPA) Administered in the Diet to CD (Sprague-Dawley) Rats
　Rochelle W. TYL (Center for Life Sciences and Toxicology, Research Triangle Institute, U.S.A.)
In vivo Effects of Nonylphenols on Reproductive Development in Pre-Adolescent Rats: Dose Response Considerations.
　Ping C. LEE (Medical College of Wisconsin, U.S.A.)
　Commentators:
　　Chiharu TOHYAMA (National Institute for Environmental Studies, Japan)
　　James C. LAMB IV (BBL Sciences, U.S.A.)
Bisphenol A Alters Development in Mice at Human Exposure Levels
　Frederick S. vom SAAL (University of Missouri-Columbia, U.S.A.)
Two-Generation Reproduction Study of Bisphenol A in Rats
　Makoto EMA (National Institute of Health Sciences, Osaka Branch, Japan)
　Commentators:
　　Jun KANNO (Biological Safety Research Center, National Institute of Health Sciences, Japan)
　　Osamu TSUTSUMI (University of Tokyo, Japan)
　　James P. KARIYA (Environmental Protection Agency, U.S.A.)

Session 6 - Risk Management

Abstracts of Session 6 Risk Management [PDF]

Chairperson:
　Tsuguyoshi SUZUKI (President, Japan Society of Endocrine Disrupter Research, Japan)

Material Cycles Society and Controlling Persistent Chemicals
　Shinichi SAKAI (Environment Preservation Center, Kyoto University, Japan)
UK Government Activities on Endocrine Disrupting Chemicals
　Kathleen CAMERON (Department of the Environment, Transport and the Regions (DETR), U.K.)
Current US Practice in Assessing Risk of Endocrine Disruptors
　Gary E. TIMM (Environmental Protection Agency (EPA), U.S.A.)
Strategic Programs on Environmental Endocrine Disrupters'98
　Masatoshi KANAI (Director, Office of Environmental Risk Assessment, Environmental Health and Safety Division, Environmental Health Department, Environment Agency, Government of Japan)