保健・化学物質対策
Medaka : 英文冊子「MEDAKA」－内分泌攪乱作用の検出の為の試験法等－
Development of Test Methods and Suitability of Medaka as Test Organism
for Detection of Endocrine Disrupting Chemicals
February 2003
Ministry of the Environment, Japan
Chemicals Evaluation and Research Institute, Japan
Documents
ALL of Docments for Japanese OS Users [PDF 3,383KB]
ALL of Docments for English OS Users [PDF 3,181KB]
| Japanese OS users | English OS users | ||
| Cover | JP [PDF] | EN [PDF] | |
| Contents | JP [PDF] | EN [PDF] | |
| Preface | JP [PDF] | EN [PDF] | |
| Summary | JP [PDF] | EN [PDF] | |
| Chapter 1: | Suitability of Medaka fish as Test Organism and New Medaka Strains | JP [PDF] | EN [PDF] |
| Chapter 2: | Receptor Binding Assay and Reporter Gene Assay of Medaka | JP [PDF] | EN [PDF] |
| Chapter 3: | Medaka Screening and Definitive Test for Endocrine Disrupting Chemicals |
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| Part 1: | Validation with Reference Chemicals |
JP [PDF] | EN [PDF] |
| Part 2: | Hazard Assessment of Tributyltin (TBT) and 4-Nonylphenol (NP) |
JP [PDF] | EN [PDF] |
| Chapter 4: | Genetic Approaches to Understanding the Basic Mechanisms of Endocrine Disruptor Actions on sex Determination/Differentiation in the Medaka, Oryzias latipes |
JP [PDF] | EN [PDF] |
| Further Works | JP [PDF] | EN [PDF] | |
| Appendix I | I The medaka(Oryzias Latipes) Partial Life-Cycle Test Guideline |
JP [PDF] | EN [PDF] |
II The medaka(Oryzias Latipes) Full Life-Cycle Test Guideline |
JP [PDF] | EN [PDF] | |
| Appendix II | I Effect of ethinylestradiol on the reproduction and induction of vtellogenin and tests-ova in Medaka(Oryzias Latipes) | JP [PDF] | EN [PDF] |
II Life-cycle toxicity of 4-nonylphenol to Medaka (Oryzias Latipes) |
JP [PDF] | EN [PDF] | |
| Appendix III | Other information regarding Medaka studies |
JP [PDF] | EN [PDF] |