保健・化学物質対策

The 3rd International Medaka Symposium, 2003Development of Test Methods with Medaka to Detect Endocrine Disrupting Chemicals

February 27 and 28, 2003 Okazaki Conference Center, Okazaki, Japan

Updated on March 14, 2003

Organizer : Ministry of the Environment, Government of Japan

Cooperated by: Chemical Evaluation and Research Institute, Japan
       Okazaki National Research Institutes, Japan

Dates : February 27 (Thursday) to February 28(Friday), 2003

Programs and Presentation Topics:

Cover [PDF]

Full Documents [Japanese [PDF] / English [PDF]]

February 27, Thursday

Development of Test Methods with Medaka to Detect Endocrine Disrupting Chemicals

Opening Address (9:30-9:45)

Abstract [Japanese [PDF] / English [PDF]]

I. Kazuhiko Adachi: Director of Environmental Health and Safety Division, Ministry of the Environment, Japan
II. Taisen Iguchi: Center for Integrative Bioscience, Okazaki National Research Institutes, Japan
III. Anne Gourmelon: Environmental Health and Safety Division, OECD

Session I Each Fish's Activity of Evaluation of Endocrine Disrupting Chemicals

[Japanese [PDF] / English [PDF]]


(Chairperson: Anne Gourmelon)

9:45-10:00
Medaka (Taisen Iguchi: Okazaki National Research Institutes)
10:00-10:45
Zebra fish (Thomas Braunbeck: Heidelberg University)
10:45-11:30
Fathead minnow (Karen Thorpe: University of Exeter/AstraZeneca)

Special Lecture Sex Determination and Gonadal Sex Differentiation in Fish (13:00-14:00)

[Japanese [PDF] / English [PDF]]

Yoshitaka Nagahama: National Institute for Basic Biology (Chairperson: Taisen Iguchi)

Session II Endocrine Disrupting Effects and Test Methods with Medaka

[Japanese [PDF] / English [PDF]]

Part I (Chairperson: Taisen Iguchi)
14:00-14:25
Availability of Receptor Binding Assay for Screening of Endocrine Disrupting Chemicals (Makoto Nakai: CERI, Japan)
14:25-14:55
Endocrine Disrupting Effects and Testing Methods with Medaka (Masanori Seki: CERI, Japan)
14:55-15:25
Partial Life-cycle Test and Full Life-cycle Test in Medaka (Hirofumi Yokota: CERI, Japan)
Part II (Chairperson: Koji Arizono)
15:40-16:05
Relationship Between Vitellogenin and Genetic Sex in Medaka Partial Life-cycle Test with the Novel Sex Determining Gene, DMY (Tatsuo Abe: CERI, Japan)
16:05-16:30
Transgenic See-Through Medaka for Monitoring Chemical Substances in Aquatic Environments (Yuko Wakamatsu: Nagoya University, Japan & Masato Kinoshita: Kyoto University, Japan)
16:30-16:55
Feeding and Preparing Endocrine-Disrupting Chemicals Free Food (Koji. Arizono: Prefectural University of Kumamoto, Japan)

16:55-17:00
Other information, medaka report (Chisumi Eto: CERI, Japan)
[Japanese [PDF] / English [PDF]]
 
 

Closing

17:00
Kenjiro Ozato: Emeritus Professor of Nagoya University, Japan [Japanese [PDF] / English [PDF]]

February 28, Friday

Technical Meeting and Strategy on Phase 1 Test Session I. OECD's Framework and Recent Studies with Three Fish Species [Abstract is not prepared - program only -]

Session I OECD's Framework and Recent Studies with Three Fish Specie
(Chairpersons: Taisen Iguchi, Rodney D. Johnson and Anne Gourmelon)

10:00-11:40
Report on the Results of Positive Controls, such as EE2, E2 and MT etc. with three Fish Species
10:00-10:30
Medaka (Masanobu Maeda: CERI, Japan)
10:30-11:00
Zebrafish (Gitte Petersen: DHI Water and Environment)
11:00-11:30
Fathead minnow (Rodney Johnson: EPA, USA)
11:30-11:40
Discussion

Session II Sensitivity and/or Variance of Parameters such as Vitellogenin and Gonad Histology for Three Fish Species
(Chairpersons: Taisen Iguchi, Rodney D. Johnson and Anne Gourmelon)

Part I
12:40-14:10
Vitellogenin (for methodology, antibody and standard)
12:40-13:00
Medaka (Norihisa Tatarazako: National Institute for Environmental Studies, Japan)
13:00-13:20
Zebrafish (Thomas Braunbeck: Heidelberg University)
13:20-13:40
Fathead minnow (Karen Thorpe; University of Exeter/AstraZeneca)
13:40-14:10
Discussion
Part II
14:25-16:00
Gonadal Historogy (for methodology and endpoints available for each fish including secondary sex characteristics)
14:25-14:45
Medaka (Masanori Seki: CERI, Japan)
14:45-15:05
Zebrafish (Leif Norrgren: Swedish University of Agricultural Sciences)
15:05-15:25
Fathead minnow (Rodney Johnson: EPA, USA)
15:25-16:05
Discussion
Part III
16:05-16:30
Draft Protocol of Phase 1 Test and Other Issues 
General Discussion
16:30
Closing