保健・化学物質対策
International Symposium on Environmental Endocrine Disrupters 2001
Contents
I. International Symposium on Environmental Endocrine Disrupters 2001 Report
Record Photographs
Program
List of Speakers
Lecture
Saturday, December 15, 2001 (Sessions Open to the Public)
Welcome Address
Yoriko Kawaguchi (Minister of the Environment)
Masaru Hashimoto (Governor, Ibaraki Prefectural Government)
Hiroshi Hase (Member of the House of Representatives)
Shuichi Kato (Member of the House of Councilors)
Special Lecture
POPs - Persistent Organic Pollutants
Bo Jansson (Stockholm University, Sweden)
Part 1 Current Strategy in Japan
Current Strategies against Environmental Endocrine Disrupters by the Ministry of the Environment, Government of Japan
Kazuhiko Adachi (Ministry of the Environment, Government of Japan)
Efforts and Strategies to Deal with the Issue of Endocrine Disruptors in Japan Results of a Nationwide Survey by the Ministry of the Environment
Shinsuke Tanabe (Center for Marine Environmental Studies, Ehime University, Japan)
The Current Situation of Human Fetal Exposure to Several Endocrine Disruptors in Japan
Chisato Mori (Graduate School of Medicine, Chiba University, Japan)
Testing System for Hazard Assessment of Endocrine Disruptors in Fish
Hirofumi Yokota (Chemicals Evaluation and Research Institute (CERI), Japan
An Approach for Evaluating Low-dose Effects of Suspected Endocrine Disruptors
Hiroaki Aoyama (Institute of Environmental Toxicology, Japan)
Development of a Test Method for Risk Assessment of Endocrine Disrupting Chemicals Using DNA Microarray Technology
Akihiro Kondo (Biotechnology Research Laboratory, Takara Shuzo Co., Ltd., Japan)
UK-J Research Project for the Endocrine Disrupters in the Aquatic Environment
Koji Arizono (Prefectural University of Kumamoto, Japan)
Endocrine Disrupters Research in National Institute for Environmental Studies
Masatoshi Morita (National Institute for Environmental Studies (NIES), Japan)
Part 2 Panel Discussion
“Environmental Hormones in the 21st Century - Searching for Widely Applicable Approaches”
General Comment
Masashi Yatabe (Commentator, Japan Broadcasting Corporation (NHK), Japan)
Environment and Doping
Ichiro Kono (University of Tsukuba, Japan)
Environmental Hormones and Nonlinear Science
Kazuyuki Aihara (Graduate School of Frontier Sciences, University of Tokyo, Japan)
Biological Systems and Chemical Substances
Takeshi Yoro (Kitasato University, Japan)
Sunday, December 16, 2001 (Expert Sessions)
Session 1 Effects on the Brain and Behavioral Development
Brain Development and Behavior as a Toxic Target of Dioxin and Other Environmental Chemicals
Bernard Weiss [Representation: Rieko Hojo] (University of Rochester School of Medicine and Dentistry, U.S.A.)
Commentators:
Chiharu Tohyama (National Institute for Environmental Studies (NIES), Japan)
Thyroid Hormone, Brain Development, and the Environment
R. Thomas Zoeller (University of Massachusetts, U.S.A.)
Commentators:
Noriyuki Koibuchi (Gunma University School of Medicine, Japan)
Functional Development of Neuronal Networks in Culture
- An in vitro Assay System of Developing Brain for Endocrine Disruptors
Yoichiro Kuroda [Representation: Masahiro Kawahara] (Tokyo Metropolitan Institute for Neuroscience, Japan)
Risk Analysis of Endocrine Disrupting Chemicals Using Higher Animals
Yasuhiro Yoshikawa (Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan)
Evidence for the Role of Environmental Neurotoxicants in Learning and Behavioral Disabilities
Deborah C. Rice (U.S. Environmental Protection Agency (EPA), U.S.A.)
Session 2 Screening and Testing Methodology
International Initiatives to Develop a Global Strategy on Endocrine Disruptors Testing and Assessment
Herman B.W.M. Koëter (OECD)
Progress in the International Harmonization of Estrogen Screens
J. William Owens (Procter & Gamble, U.S.A)
Testing Strategies for Endocrine Disruption in the Aquatic Environment
Daniel B. Pickford (AstraZeneca Global Safety Health and Environment, U.K.)
Screening and Testing of Endocrine Disruptors in Avian Species Present status and future direction
Masaru Wada (Tokyo Medical and Dental University, Japan)
Recent Research of Endocrine Disrupters Testing of Amphibians in Japan
Minoru Uchiyama (Toyama University, Japan)
Session 3 High Throughput Pre-Screening (HTPS) and Quantitative Structure-Activity Relationship (QSAR) Techniques
HTPS and QSAR:
Screening Methods and Cutting Edge Sciences in Endocrine Disruptor Issue
Jun Kanno (National Institute of Health Sciences, Japan)
Priority Setting of Endocrine Disruptors Using QSARs
Weida Tong (FDA's National Center for Toxicological Research (NCTR), U.S.A.)
3D-SAR Analysis of EDs Based on Target Receptor Structure
Nobuo Tomioka, Akiko Itai (Institute of Medicinal Molecular Design, Inc., Japan)
Efficacy of Highthroughput Pre-Screening Procedure Based on Reporter Gene Assay
Masahiro Takeyoshi (Chemicals Evaluation and Research Institute (CERI), Japan)
A New Approach to Functional Genomics
Bruce Blumberg (University of California, U.S.A.)
Combinatorial Phage Library Screening for Estrogen Receptor Interacting Peptides and Applications to the Study of Xenoestrogen Biology and Pharmacology
Julianne M. Hall (National Institute of Environmental Health Sciences, U.S.A.)
Night Session Toxico-Genomics
Functional Genomics Towards Understanding of the Mechanisms of Life
Yuji Kohara (National Institute of Genetics, Japan)
Toxicogenomics and Its Potential for Assessment of Pollutant Impact in Fish
Tim Williams (The University of Birmingham, U.K.)
Progress in Medaka Genomics
Kiyoshi Naruse (Graduate School of Science, University of Tokyo, Japan)
Status of Xenopus laevis and Xenopus tropicalis microarrays
Bruce Blumberg (University of California, U.S.A.)
Toxicogenomic Assessment of Endocrine Disruptors
Timothy Richard Zacharewski (Michigan State University, U.S.A.)
Molecular Profiling of Genes Showing Altered Expression in the Livers of Rats Treated with Non-Genotoxic Carcinogens for 28 Days
Makoto Shibutani (National Institute of Health Sciences, Japan)
Fetal Transcript Profiles for Endocrine Disrupters
George P. Daston (The Procter & Gamble Company, U.S.A.)
Monday, December 17, 2001 (Expert Sessions)
Session 4 Effects on Wildlife
Endocrine Disruption in Aquatic Invertebrates
Michael H. Depledge (Plymouth Environmental Research Centre, University of Plymouth, U.K.)
Endocrine Disruptor Susceptibility Genes:
Molecular Analysis of Aryl Hydrocarbon Receptors and Dioxin Sensitivity in Wildlife
Mark E. Hahn (Woods Hole Oceanographic Institution, U.S.A.)
The Effects of Endocrine Disruptors on Fish Maturation and Reproduction -A Focus on Projects Underway at the Ministry of Agriculture, Forestry, and Fisheries-
Kazunori Fujii (National Research Institute of Fisheries and Environment of Inland Sea, Fisheries Research Agency, Japan)
Atrazine Produces Hermaphrodites in Frogs: Connecting Laboratory and Field Studies
Tyrone B. Hayes (University of California, Berkeley, U.S.A.)
Beyond Estrogens -Multiple Mechanisms of Endocrine Disruption
Louis J. Guillette, Jr. (University of Florida, U.S.A.)
Session 5 Effects on Health
Salutations
Kenji Manabe (Member of the House of Councilors)
Birth Defects Monitoring in Japan -Possible Effects of Environmental Endocrine Disruptors-
Fumiki Hirahara (Yokohama City University School of Medicine, Japan)
Cryptorchidism and Hypospadias in The Netherlands: Are Endocrine Disrupters Involved?
Frank H. Pierik (Erasmus University Rotterdam, The Netherlands)
Trends in Male Reproductive Health
Paul A.L. Lancaster (University of New South Wales, Australia)
1,1-Dichloro-2,2-Bis (P-Chlorophenyl) Ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five US Studies
David J. Hunter (Harvard Medical School and School of Public Health, U.S.A.)
Session 6 Reports on Overseas Activities
Keynote Presentation:
The WHO/UNEP/ILO International Programme on Chemical Safety (IPCS) Global Assessment of the State-of-the-Science of Endocrine Disrupting Chemicals (EDCs)
Robert J. Kavlock (U.S. Environmental Protection Agency (EPA), U.S.A.)
Progress in Implementing the Endocrine Disruptor Screening Program
Gary E. Timm (U.S. Environmental Protection Agency (EPA), U.S.A.)
Chemical Industry’s Research Program on Hormonally Active Agents (HAAs)
Judith A. Graham (American Chemistry Council, U.S.A.)
Research on Endocrine Disruption in the UK
Kathleen Cameron (DEFRA, U.K.)
Endocrine Disruptors Research in Malaysia
Mustafa Ali Mohd (University of Malaya, Malaysia)
Closing Address
Soichiro Iwao (Ministry of the Environment, Government of Japan)