Health & Chemicals

Progress of Reliability Evaluation and Tests

Based on EXTEND 2010 and EXTEND 2016, Ministry of the Environment (MOE) is implementing reliability evaluation of literatures and two-tiered framework for testing and assessment (see "Further Actions on Endocrine Disrupting Effects of Chemical Substances ― EXTEND2016 ―" (Tentative Translation) (June 2016)[PDF 1,024KB] for further details).

  • "Reliability evaluation": Reliability of existing knowledge and information on the concerned chemicals are evaluated.
  • "Tier 1": Prioritization of "Chemicals that can be subjected to tests for endocrine disrupting effects" identified through the reliability evaluation, and implementation of Tier 1 testing.
  • "Tier 2": Implementation of Tier 2 testing. "Chemicals with actions relevant to endocrine disruption" judged through Tier 1 assessment are to be candidates.

The following table is the list of chemical substances which MOE has implemented evaluation and/or testing. Only the summary of results and Tier 1 in vivo test results are available in English.

Chemicals CAS Current status Summary of results Evaluation / detail of test results
Reliability Evaluation Tier 1 Tier 2
in vitro in vivo Assessment in vivo
Chemicals CAS Current status Summary of results Evaluation / detail of test results
Reliability Evaluation Tier 1 Tier 2
in vitro in vivo Assessment in vivo
Acrylamide 79-06-1 [Figure] Summary 2010 2012, 2018 - - -
Acrylic acid 79-10-7 [Figure] Summary 2010 - - - -
Acrylonitrile 107-13-1 [Figure] Summary 2015 2017, 2018 - - -
Acrolein 107-02-8 [Figure] Summary 2011 - - - -
Adipic acid 124-04-9 [Figure] Summary 2009 - - - -
Acetamiprid 135410-20-7
160430-64-8etc.		 [Figure] Summary 2019 2021 P    
6-Acetyl-1,1,2,4,4,7-hexamethyltetralin (Tonalide or AHTN) 1506-02-1
21145-77-7		 [Figure] Summary 2017 2017 P    
Acetaldehyde 75-07-0 [Figure] Summary 2013 - P    
Acephate 30560-19-1 [Figure] Summary 2017 - P    
Azoxystrobin 131860-33-8 [Figure] Summary 2019 2021 P    
Atrazine 1912-24-9 [Figure] Summary 2011 2013, 2015 - - -
Amiodarone 1951-25-3 [Figure] Summary 2019 P      
Alachlor 15972-60-8 [Figure] Summary 2010 2012 - - -
Benzyl benzoate 120-51-4 [Figure] Summary 2019 P      
EPN 2104-64-5 [Figure] Summary 2009 - - - -
Isocyanurate 108-80-5 [Figure] Summary P        
Iprodione 36734-19-7 [Figure] Summary 2017 2017 - - -
Imidacloprid 105827-78-9 [Figure] Summary 2018 P      
17β-Estradiol 50-28-2       2016, 2017, 2018 2015 2016 P
Estrone 53-16-7 [Figure] Summary 2008 2011, 2018 2011, 2017 2016 2017, 2018
17α-Ethynylestradiol 57-63-6       2017, 2018 2015 2016 2019, 2020
2-Ethylhexanoic acid 149-57-5 [Figure] Summary 2015 - - - -
Ethylbenzene 100-41-4 [Figure] Summary 2014 P      
Ethylene oxide 75-21-8 [Figure] Summary 2015 - P    
Ethylene glycol (Ethylene glycol) 107-21-1 [Figure] Summary 2019 - - - -
Ethylene glycol monoethyl ether 110-80-5 [Figure] Summary 2016 2017, P      
Ethylene glycol monomethyl ether 109-86-4 [Figure] Summary 2016 P      
Ethylenediaminetetraacetic acid 60-00-4 [Figure] Summary 2015 - - - -
Ethylene thiourea (Imidazolidine-2-thione) 96-45-7 [Figure] Summary 2020 P      
Epichlorohydrin 106-89-8 [Figure] Summary 2012 - P    
Erythromycin 114-07-8 [Figure] Summary 2017 - P    
Vinyl chloride monomer 75-01-4 [Figure] Summary 2012 - - - -
Methyl chloride 74-87-3 [Figure] Summary 2015 - - - -
Octabromodiphenyl ether 32536-52-0 [Figure] Summary 2015 - - - -
Octamethylcyclotetrasiloxane 556-67-2 [Figure] Summary P        
4-tert-Octylphenol 140-66-9 [Figure] Summary 2014 2008, 2015, 2017 2014 2016 2017, 2018, 2019
Hydronium perchlorate 7601-90-3 [Figure] Summary 2013 2014, P - - -
Caffeine 58-08-2 [Figure] Summary P        
Carbamazepine 298-46-4 [Figure] Summary P        
Carbaryl 63-25-2 [Figure] Summary 2009 2011, 2015, 2017 P    
Carbendazim 10605-21-7 [Figure] Summary 2014 2015, 2018 - - -
Carbofuran 1563-66-2 [Figure] Summary 2009 2011, 2015, 2018 - - -
Xylenes o-キシレン
o-Xylene
（95-47-6）
m-キシレン
m-Xylene
（108-38-3）
p-キシレン
p-Xylene
（106-42-3）		 [Figure] Summary 2012 - P    
Clarithromycin 81103-11-9 [Figure] Summary 2017 - P    
Glyphosate 1071-83-6 [Figure] Summary 2013 2017, 2018 - - -
Clindamycin 18323-44-9 [Figure] Summary 2017 - - - -
Cresols o-クレゾール
o-Cresol
(95-48-7)
m-クレゾール
m-Cresol
(108-39-4)
p-クレゾール
p-Cresol
(106-44-5)		 [Figure] Summary 2012 - - - -
Clothianidin 210880-92-5 [Figure] Summary 2018 2021 P    
Clotrimazole 23593-75-1 [Figure] Summary 2020 P      
Clomipramine 303-49-1 [Figure] Summary 2021 P      
Chlorpyrifos 2921-88-2 [Figure] Summary 2016 2017,
2021		 P    
Chlorothalonil (TPN) 1897-45-6 [Figure] Summary 2015 2017 - - -
Chlorobenzene 108-90-7 [Figure] Summary 2012 - P    
Chloroform 67-66-3 [Figure] Summary 2012 - - - -
2-Ethoxyethanol acetate 111-15-9 [Figure] Summary 2014 - - - -
Chlormadinone acetate 302-22-7 [Figure] Summary 2015 2016, 2017, 2018 P    
Salicylates (as sodium salt) 54-21-7 [Figure] Summary 2021 - - - -
Cyanazine 21725-46-2 [Figure] Summary 2009 2011 2011 2016 P
Cyanamide 420-04-2 [Figure] Summary 2019 P      
Cyanide (including Hydrogen cyanide) 74-90-8etc. [Figure] Summary 2019 - - - -
Diuron 330-54-1 [Figure] Summary 2009 2011, 2015 P    
Diethylene glycol 111-46-6 [Figure] Summary 2011 - - - -
Carbon tetrachloride 56-23-5 [Figure] Summary 2012 - - - -
Diclofenac 15307-86-5 [Figure] Summary 2019 P      
Dichlobenil (DNB) 1194-65-6 [Figure] Summary 2018 2020, P      
Dichlorvos 62-73-7 [Figure] Summary 2009 2011 - - -
3,4-Dichloroaniline 95-76-1 [Figure] Summary 2014 P      
1,2-Dichloroethane 107-06-2 [Figure] Summary 2015 - - - -
1,1-Dichloroethylene (Vinylidene chloride) 75-35-4 [Figure] Summary 2015 - - - -
Dichloroacetic acid 79-43-6 [Figure] Summary 2014 P      
2,4-Dichlorophenol 120-83-2 [Figure] Summary 2017 2018, P P    
2,4-Dichlorophenoxyacetic Acid (2,4-D, 2,4-PA) 94-75-7 [Figure] Summary 2010 2012, 2018, P - - -
Dichlorobromomethane 75-27-4 [Figure] Summary 2009 2011, 2015 - - -
p-Dichlorobenzene 106-46-7 [Figure] Summary 2008 2010 - - -
o-Dichlorobenzene 95-50-1 [Figure] Summary 2008 - - - -
Dichloromethane 75-09-2 [Figure] Summary 2012 - - - -
Diquat 80-00-7 [Figure] Summary 2017 - - - -
2,4-Dinitrotoluene 121-14-2 [Figure] Summary 2014 P      
2,4-Dinitrophenol 51-28-5 [Figure] Summary 2012 2013 - - -
Dinocap 131-72-6 [Figure] Summary 2010 - - - -
Difenoconazole 119446-68-3 [Figure] Summary 2018 P      
Dibutyltins ジクロリド (683-18-1) Dichloride (683-18-1) etc. [Figure] Summary 2017 2018 P    
Dibromochloromethane 124-48-1 [Figure] Summary 2015 2017, 2018 - - -
Cypermethrin 52315-07-8 etc. [Figure] Summary 2018 2020, P      
Simazine 122-34-9 [Figure] Summary 2012 2013, 2017, P - - -
N,N-Dimethylacetamide 127-19-5 [Figure] Summary 2017 - - - -
Dimethyl sulfoxide 67-68-5 [Figure] Summary 2019 P      
N,N'-Dimethylformamide 68-12-2 [Figure] Summary 2008 2010 - - -
Dimethoate 60-51-5 [Figure] Summary 2016 2017, 2018 - - -
Methyl bromide (Bromomethane) 74-83-9 [Figure] Summary － - - - -
Ziram 137-30-4 [Figure] Summary 2015 2016 - - -
Styrene 100-42-5 [Figure] Summary 2015 2016, P      
Spinosad スピノシンA(131929-60-7)とスピノシンD(131929-63-0)の混合物
Mixture of Spinosyn A (131929-60-7) and Spinosyn D (131929-63-0)		 [Figure] Summary 2015 - - - -
Sulfadiazine 68-35-9 [Figure] Summary 2017 - - - -
Sulfapyridine 144-83-2 [Figure] Summary 2017 - - - -
Sulfamethoxazole 723-46-6 [Figure] Summary 2017 2017 2021 P  
Sertraline 79617-96-2 [Figure] Summary 2018 2020, P      
Diazinon 333-41-5 [Figure] Summary 2009 2011, 2015 2015 2016 P
Thiabendazole 148-79-8 [Figure] Summary P        
Thiamethoxam 153719-23-4 [Figure] Summary 2019 2021 - - -
Thiuram 137-26-8 [Figure] Summary 2012 - P    
Thiocyanates 463-56-9etc. [Figure] Summary 2020 - - - -
Thiourea 62-56-6 [Figure] Summary 2015 2016, P      
Thiophanate methyl 23564-05-8 [Figure] Summary 2018 - - - -
Thiobencarb 28249-77-6 [Figure] Summary 2012 - - - -
Linear alkylbenzene sulfonic acids and their salts (C=10-14) C-10(31093-47-4,1322-98-1)
C-11(27636-75-5)
C-12(25155-30-0)
C-13(26248-24-8)
C-14(28348-61-0) etc.		 [Figure] Summary 2008 - - - -
Decabromodiphenyl ether (PBDE#209) 1163-19-5 [Figure] Summary 2012 2013, 2015 - - -
Decamethylcyclopentasiloxane 541-02-6 [Figure] Summary P        
Tetrachloroethylene 127-18-4 [Figure] Summary 2012 - - - -
Tetrachlorobenzenes 1,2,4,5-テトラクロロベンゼン
1,2,4,5-Tetrachlorobenzene
（95-94-3）
1,2,3,4-テトラクロロベンゼン
1,2,3,4-Tetrachlorobenzene
（634-66-2）
1,2,3,5-テトラクロロベンゼン
1,2,3,5-Tetrachlorobenzene
（634-90-2）		 [Figure] Summary 2010 - - - -
2,2',4,4'-Tetrahydroxybenzophenone (Benzophenone-2) 131-55-5 [Figure] Summary 2017 2017, 2021 2018 P  
Tetrabromobisphenol A 79-94-7 [Figure] Summary 2010 2012, 2021 - - -
Tebuconazole 107534-96-3 [Figure] Summary 2015 2016, 2017 - - -
Tebufenozide 112410-23-8 [Figure] Summary 2015 2017 2018    
Dodecamethylcyclohexasiloxane 540-97-6 [Figure] Summary P        
Triclosan 3380-34-5 [Figure] Summary 2014 2015, 2017 2016 2017 P
Triclopyr 55335-06-3 [Figure] Summary 2017 - - - -
Trichlorphene (DEP) 52-68-6 [Figure] Summary 2016 - P    
1,1,1-Trichloroethane 71-55-6 [Figure] Summary 2012 - - - -
Trichloroethylene 79-01-6 [Figure] Summary 2012 - P    
Trichloroacetic acid 76-03-9 [Figure] Summary 2014 2015, 2017 - - -
1,2,3-Trichloropropane 96-18-4 [Figure] Summary 2012 - - - -
Trichlorobenzenes 1,2,3-トリクロロベンゼン
1,2,3-Trichlorobenzene
(87-61-6)
1,2,4-トリクロロベンゼン
1,2,4-Trichlorobenzene
(120-82-1)
1,3,5-トリクロロベンゼン
1,3,5-Trichlorobenzene
(108-70-3)		 [Figure] Summary 2010 - - - -
Trifluralin 1582-09-8 [Figure] Summary 2008 - - - -
2,4,6-Tribromophenol 118-79-6 [Figure] Summary 2008 2010, 2012 P    
1,7,7-trimethyl-3-(phenylmethylene)bicyclo[2.2.1]heptan-2-one (3-Benzylidene camphor) 15087-24-8 [Figure] Summary 2020 P      
1,7,7-trimethyl-3-[4-(methylphenyl)methylene]bicyclo[2.2.1]heptan-2-one (4-Methlbenzylidene camphor) 36861-47-9 [Figure] Summary 2020 P      
Trimethoprim 738-70-5 [Figure] Summary 2017 - - - -
Toluene 108-88-3 [Figure] Summary 2012 - P    
2,4-Diaminotoluene 95-80-7 [Figure] Summary 2008 2010 - - -
2,4-Toluene Diisocyanate 584-84-9 [Figure] Summary 2017 - - - -
2,6-Toluene Diisocyanate 91-08-7 [Figure] Summary 2017 - - - -
Naphthalene 91-20-3 [Figure] Summary 2010 2012 - - -
1-Naphthol 90-15-3 [Figure] Summary 2011 2012 2012 2016 P
2-Naphthol 135-19-3 [Figure] Summary 2019 P      
p-Nitrophenol 100-02-7 [Figure] Summary 2018 2020 - - -
Nitrobenzene 98-95-3 [Figure] Summary 2013 2017, 2018 - - -
Carbon disulfide 75-15-0 [Figure] Summary 2013 2014, 2017, 2018 - - -
Nonabromodiphenyl ethers 63936-56-1 etc. [Figure] Summary 2017 P      
4-Nonylphenol (branched) 84852-15-3 [Figure] Summary 2014 2008, 2015, 2017 2014 2016 2015
Paraquat 1910-42-5 [Figure] Summary 2019 2021 P    
Valproate 99-66-1 [Figure] Summary P        
Paroxetine 61869-08-7 [Figure] Summary 2019 P      
Bisphenol A 80-05-7 [Figure] Summary 2015 2008, 2015, 2017 2015 2016 2016, 2017, 2018, 2019
Hydrazine 302-01-2 [Figure] Summary 2008 2010 - - -
Propyl 4-Hydroxybenzoate (Propyl Paraben) 94-13-3 [Figure] Summary 2015 2016, 2021 2017, 2018 P  
Methyl 4-Hydroxybenzoate 99-76-3 [Figure] Summary 2012 2013, P 2014 2016 P
Hydroquinone 123-31-9 [Figure] Summary 2012 P      
Hydrochlorothiazide 58-93-5 [Figure] Summary 2021 - - - -
4-Vinyl-1-cyclohexene 100-40-3 [Figure] Summary 2016 P      
Pyridostigmine 155-97-5 [Figure] Summary P        
Pyriproxyfen 95737-68-1 [Figure] Summary 2018 2020, P      
Pyrene 129-00-0 [Figure] Summary 2017 2018, P      
Fipronil 120068-37-3 [Figure] Summary 2014 2015, 2017 - - -
Phenanthrene 85-01-8 [Figure] Summary 2009 - - - -
Phenytoin 57-41-0 [Figure] Summary 2009 2011, P 2011 2016 P
Fenitrothion 122-14-5 [Figure] Summary 2009 2011, 2015, 2017, 2018, P 2018 P  
o-Phenyl phenol 90-43-7 [Figure] Summary 2018 2020 - - -
Phenol 108-95-2 [Figure] Summary 2012 2013, 2015, 2018 - - -
Phenobarbital 50-06-6 [Figure] Summary 2009 2012 - - -
Fenthion 55-38-9 [Figure] Summary 2008 2010, 2011, 2018 - - -
Fenvalerate 51630-58-1 [Figure] Summary 2013 2014, 2017 2015 2016 P
Butachlor 23184-66-9 [Figure] Summary 2015 2016, 2018 - - -
1,3-Butadiene 106-99-0 [Figure] Summary 2017 - - - -
1-Butanol 71-36-3 [Figure] Summary 2009 - - - -
Diisobutyl phthalate 84-69-5 [Figure] Summary 2014 2015, 2017, 2018 2017 P  
Di(2-ethylhexyl phthalate) 117-81-7 [Figure] Summary 2020 P      
di(n-Octyl)Phthalate 117-84-0 [Figure] Summary 2017 P      
Dimethyl phthalate 131-11-3 [Figure] Summary 2010 - - - -
4-tert-Butylphenol 98-54-4 [Figure] Summary 2019 2021 P    
2,6-Di-tert-butyl-4-methylphenol (BHT) 128-37-0 [Figure] Summary 2011 2012 - - -
2-Butoxyethanol (Ethylene glycol monobutyl ether) 111-76-2 [Figure] Summary 2015 - - - -
Fluoranthene 206-44-0 [Figure] Summary 2015 2016, 2017 - - -
Flutamide 13311-84-7 [Figure] Summary 2013 2014, 2017, 2018 P    
Flutolanil 66332-96-5 [Figure] Summary 2018 2020 - - -
Procymidone 32809-16-8 [Figure] Summary 2015 2016, 2018 P    
2-Propanol 67-63-0 [Figure] Summary 2011 - - - -
Propargite 2312-35-8 [Figure] Summary 2018 P      
Propiconazole 60207-90-1 [Figure] Summary 2015 2016, 2017 - - -
Propyzamide 23950-58-5 [Figure] Summary 2018 P      
2-Bromopropane 75-26-3 [Figure] Summary 2015 2016 - - -
1-Bromopropane 106-94-5 [Figure] Summary 2015 2016 - - -
1,2,5,6,9,10-Hexabromo-cyclododecanes 3194-55-6 etc. [Figure] Summary - - - - -
n-Hexane 110-54-3 [Figure] Summary 2017 2021 - - -
Bezafibrate 41859-67-0 [Figure] Summary 2021 - - - -
Benomyl 17804-35-2 [Figure] Summary 2014 2015, 2017, 2021 P    
Pentadecafluorooctanoic acid 335-67-1 [Figure] Summary 2009 2011, 2015, P P    
Perfluorododecanoic acid 307-55-1 [Figure] Summary 2015 2016, P      
Permethrin 52645-53-1etc. [Figure] Summary 2020 P      
Benzyl alcohol 100-51-6 [Figure] Summary 2009 - - - -
Benzylparaben 94-18-8 [Figure] Summary P        
Benzene 71-43-2 [Figure] Summary 2012 - P    
4-tert-Amylphenol 80-46-6 [Figure] Summary 2011 2012, 2015, 2018 2012 2016 P
Pendimethalin 40487-42-1 [Figure] Summary 2017 2017 2018 P  
Polyoxyethylene Nonylphenyl Ethers (Nonylphenol Ethoxylates) (polymerization degree 1-15) 9016-45-9 etc. [Figure] Summary 2017 2017, 2021 - - -
Formaldehyde 50-00-0 [Figure] Summary 2012 - - - -
Malachite Green 569-64-2 [Figure] Summary P        
Manzeb (Mancozeb) 8018-01-7 [Figure] Summary 2016 2017, 2018 P    
Maneb 12427-38-2 [Figure] Summary 2016 2017, 2018 P    
Myclobutanil 88671-89-0 [Figure] Summary 2018 2020, P      
Methomyl 16752-77-5 [Figure] Summary 2011 2012 - - -
Methyl methacrylate 80-62-6 [Figure] Summary 2009 - - - -
Metalaxyl 57837-19-1 [Figure] Summary 2018 2020 - - -
Methyl ethyl ketone 78-93-3 [Figure] Summary 2019 - - - -
Methyl cellulose and its derivatives 9004-67-5etc. [Figure] Summary 2019 - - - -
Methyl-tert-butyl ether 1634-04-4 [Figure] Summary 2015 2016, 2021 - - -
2-Methylpropan-2-ol (tert-Butyl Alcohol) 75-65-0 [Figure] Summary 2015 2016 - - -
Metformin 1115-70-4 [Figure] Summary P        
Metolachlor 51218-45-2 [Figure] Summary 2015 2016 - - -
Metribuzin 21087-64-9 [Figure] Summary 2018 P      
Mefenamic Acid 61-68-7 [Figure] Summary 2017 2018, P P    
Melamine 108-78-1 [Figure] Summary 2017 2018 - - -
Mercaptoacetic acid 68-11-1 [Figure] Summary 2010 - - - -
Monobutyltins トリクロリド
(1118-46-3) Trichloride
(1118-46-3) etc.		 [Figure] Summary 2017 - P    
Molinate 2212-67-1 [Figure] Summary 2010 2012, 2021 - - -
Linuron 330-55-2 [Figure] Summary 2016 2017, 2018 2018 P  
Tricresyl phosphate 1330-78-5 [Figure] Summary 2013 2014, 2018 2021 P  
tris(2-Chloroethyl)Phosphate 115-96-8 [Figure] Summary 2017 P      
Triphenyl phosphate 115-86-6 [Figure] Summary 2010 2012, 2013 2012 2016 P
Roxithromycin 80214-83-1 [Figure] Summary 2017 P      

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