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A-4.5.1 Identification of factors for determining genetic susceptibility to ultraviolet

[Contact Person]

Yasunobu Aoki
Section Chief
Section of Experimantal Pathlogy and Toxicology
National Institute for Environmental Studies
Environmental Agency
Onogawa 16-2, Tsukuba, Ibaraki, 305-0053 Japan
Tel; +81-298-50-2390 Fax; +81-298-50-2588
E-mail; ybaoki@nies.go.jp

Total Budget for FY1996-FY1998

17,987,000 Yen (FY1998; 5,998,000 Yen)

Abstract

We examined the dose rate-effect of UV-B irradiation on mutagenesis and related toxic effects. An action spectrum of UV-B and UV-A for mutation and cytotoxicity was also estimated. UV-B irradiation for a long duration at a low dose rate showed lower cytotoxicity than that for a short duration at a high dose rate, resulting that relative mutagenicity (number of mutations per input cells) might be elevated at the low dose rate. Our result suggests that a long exposure to weak ultraviolet is possibly more risky than a short exposure to strong ultraviolet.
Effect of UV-B irradiation on the embryogenesis of zebrafish and the mutagenesis in the embryo was investigated.

[Key Words]

HSV-tk gene, mutagenesis, dose rate, malformation, action spectrum