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[B-13.1 Effects of Heat Stress on Defence Reactions, Metabolic Activities and Heat Related Disorders]

[Contact Person]

Mitsuru Ando
Chief Research Scientist
International Health Effect Research Team,
Regional Environment Division, National
Institute for Environmental Studies,
Environment Agency
Onogawa 16-2, Tsukuba, Ibaraki, 305 Japan
Tel : +81-298-50-2395 Fax : +81-298-50-2548

[Total Budget for FY1993-1995]

32,891,000 Yen (FY 1995; 11,212,000 Yen)

[Abstract]

　Since global warming will have an increase heat stress in hot summer in some temperate big cities, various health risk caused by heat stress has been studied. According to the epidemiological survey, the incidence of heat-related illness significantly correlated to hot environment in Tokyo, Japan and in Nanjing, China . The epidemiological results showed that hyperthermia caused by heat stress induced many heat stroke patients in Tokyo, Japan and in Nanjing, China.
　Hyperthermia developed histochemical degeneration in immune systems, such as spleen, thymus, Iymphatic system. Hyperthermia also affected on biochemical function and intracellular components in hepatic cells.
　Immune reactions, such as thymus lymphocyte reaction, spleen lymphocyte reaction, and humoral antibody reaction was markedly affected in hyperthermia. Therefore global warming may have profound impacts on human defence reactions against some diseases during heat stress in hot summer.
　Since heat stress caused an increase in morbidity and mortality, oxygen radical damages in hyperthermia were studied. Since lipid peroxidation was greatly induced in liver, hyperthermia greatly developed hypertrophy and vacuolized degeneration in hepatic cells.
　Protective enzymes, such as glutathione peroxidase activities were induced in hyperthermia. Heat stress also affected central nervous systems and changed the sleeping behaviour.

[Key Words]

Heat stress, Immune system, Lymphocyte, Humoral antibody, heat stroke, Radicals