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[A-4.5 Studies on Human Health Effects by increased Ultraviolet Ray Molecular epidemiological study on skin cancer and precancerous lesion]

[Contact Person]

Watanabe, Shaw
Chief, Cancer Information and Epidemiology Division
National Cancer Center Research Institute
5-1-1, Tsukiji, Chuo-ku, Tokyo 104, Japan
Tel +81-3-3542-2511 ext 4250 or +81-3-5477-2670
Fax +81-3-5477-7222
e-mail: swatanab@ncc.go.jp

[Collaborators]
Ichihashi, Masamitsu, Professor of Dermatology, Kobe University, School of Medicine
Hayashi, Director, Akita Agrarian Medical Institute
Matsushima, Shosui, Director, Nagano Agrarian Medical
Institute
Kinjo , Director, Okinawa Prefecture, Department of Environmental Health
Inoue, Shohei, Professor of Dermatology, Miyazaki Medical College
Munakata, , Section Chief, Radiology Division,
National Cancer Center Research Institute
Takahashi, Ken, Assistant Professor, Environmental
Epidemiology, University of Industrial Medicine

[Total Budget for FY1993-1995]

(FY1995: 15,194,000 yen)

[Abstract]

　Skin cancer is one of representative biological effects of ultraviolet ray on human health. Prevalence and incidence rates of cutaneous lesions are surveyed by mass-screening program in 5 different areas in Japan. Prevalence of skin lesions were surveyed in Akita, Nagano, Hyogo, Miyazaki and Okinawa prefecture. Genetic changes of the biopsy materials were examined, and p53 alteration was found in precancerous solar keratosis. Continuous mass-screening in the same area make it possible to calculate the incidence rate. International collaboration is also important because the increasing UV exposure is the global issue.

[Key Words]

Ultraviolet ray, Skin cancer, Solar keratosis