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[A-7.1.3 Environmental Effects of Substitutes for CFCs]

[Contact Person]

Kunimitsu Kaya
Head, Chemical Toxicology Section,
Division of Environmental Chemistry, National Institute
for Environmental Studies,
Environmental Agency of Japan
16-2, Onogawa. Tsukuba. Ibaraki 305 Japan
Tel:+81-298-51-6111(Ext.297), Fax:+81-298-56-4678

[Total Budget for FY1990-1992]

18,630,000 Yen

[Abstract]

　The rate constant of the reaction between pentafluoropropanol (5FP) and OH radical was measured using a laser induced fluorescence technique, which is (8.8+-1.1)×10(-14)cc molecule/sec.
　A rapid method of toxicity test in vitro for substitutes of CFCs was developed. For efficiency test of the method, cytotoxicity and cytogenotoxicity of benzene as a cancer initiator were measured. The results of the efficiency test suggest that the method is able to use for toxicity test of CFCs Substitutes.

[Key Words]

Substitutes for CFCs,OH radical, Laser-induced fluorescence, in vitro, Cytotoxicity