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[A-4.2.3 Effects on Photoallergy]

[Contact Person]

Yamada, Hirotomo
Department of Occupational Diseases,
National Institute of Industrial Health,
Ministry of Labor
21-1, Nagao 6 chome, Tama-ku, Kawasaki, 214 Japan
Tel +81-044-865-6111, Fax +81-044-865-6116

[Total Budget for FY1990-1992]

29,370,000 Yen

[Abstract]

This study was designed to estimate risks caused by ultraviolet radiation(UVR) including photoallergy by detecting changes in proteins of human skin cells. Thus far, Gel electrophoresis of proteins from the cells harvested after radiation of shorter wave length UVB has shown increases in several protein bands, which are possible candidates of antigens which cause immune responses, such as photoallergy.
　Effects of UVR on the cells exposed to heavy metals(Hg, Cd and Zn) were studied. The double exposures to UV and a metal showed much greater lesions than simple sums of those obtained by exposure to each factor and also induced specific proteins. This means that cellular damages are determined not only by energy( joules) and wavelength(nm) of UVB but seriously affected by co-existence of other environmental factors.

[Key Words]

Monochromatic Radiation, Human Skin Cells. Heavy Metals, Photoallergy, Electrophoresis