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28,975,000 Yen
The risk of solar UV ray-increase by ozone depletion to the human health was studied by looking at possible immune depression and the amplification of infectious diseases. In the case of immune depression, it was found that effects of UV-B ray was confirmed with delayed type hypersensitivity but no effect was seen in humoral immunity after vaccination. The effect of UV-B ray in interferon induction was dependent on the injection route of the stimulus. Experimental sunburn in mice increased plasma sialic acid which has been recognized as a member of immune family. UV-B ray on infectious diseases were also examined in vitro. In lytic infection of RNA and DNA viruses, pre-irradiation by UV-B ray as well as UV-C to cultured cells did not support but rather depressed the viral growth depending on the host cell death. In persistent infection, however, the viral genome DNA was amplified by not only UV-C but also by UV-B ray. Biological character of UV-B ray was different from that of UV-C especially in mutagenicity. Pathogenicity-lost mutant of pseudotuberculosis was generated by UV-C irradiation but not by UV-B ray. Herpes virus infection in mice is a positive evidence of the effect of UV ray on infectious disease in vivo. We confirmed that BALB/C mice lost their resistance to HSV as a result of UV-B ray pre-irradiation and those mice died from herpetic encephalitis within 2 weeks. In this project, the immunopathological background of the HSV disease in mice was studied.
UV-B ray, Immune depression, Viral genome activation, Herpes simplex virus infection, Plasma sialic acid elevation