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[A-4.1 Molecular Epidemiological Study using Biological Markers like Point Mutation on the Relationship between Exposure to Ultraviolet Ray and Skin Cancer]

[Contact Person]

Shaw Watanabe
Chief, Epidemiology Division
National Cancer Center Research Institute
5-1-1, Tsukiji, Chuo-ku, Tokyo 104, Japan
FAX +81-3-3546-0630
E-mail swatanab@gan.ncc.go.jp

[Total Budget for FY1990-1992]

37,459 Yen

[Abstract]

　Analyses of trends in mortality from skin cancer in Japan and standardized mortality rates by prefecture(SMR) revealed decreased cumulative mortality rates of non-melanocytic skin cancer in both males and females in the last 30 years. SMR, however, showed higher rates in the southern part of Japan such as Okinawa, Kagoshima, Kochi, etc. These suggested the relationship between UV exposure and skin cancer.
　To find a good biomarker for premalignant state of skin cancer being related to the UV exposure, p53 aberrations in both DNA sequence and immunostaining for p53 protein was examined. Aberrations of the p53 gene in 29 solar keratosis(SKs) and 5 squamous cell carcinomas(SCCs) were examined by single-strand conformation polymorphism analysis of polymerase chain reaction products. In a series of Japanese patlents, 8/29(28%) of SKs and 2/5(40%) SCCs of the skin contains structural abnormalities of the p53 gene. We clarified that aberrations of the p53 gene were caused in SKs of early dysplasia.

[Key Words]

UV, skin cancer, solar keratosis, p53, pyrimidine dimer, epidemiology