Strategic Programs on Environmental Endocrine Disruptors '98 (SPEED '98)

Table-3: Chemicals Suspected of Having Endocrine Disrupting Effects

Substances	Use	Restrictions
1. Dioxins and furans	(Unintended product)	Air Pollution Law, Waste Disposal and Public Cleaning Law, POPs
2. Polychlorinated biphenyl (PCB)	Heat medium, non-carbon paper, electric product	Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances Class I in 1974, stopped production in 1972, Water Pollution Control Law, Marine Pollution Prevention Law, Waste Disposal and Public Cleaning Law, Environmental Quality Standards for Groundwater, Soil Pollution, and Water Pollutants, POPs
3. Polybromobiphenyl (PBB)	Fire retardant
4. Hexachlorobenzene (HCB)	Bactericide, organic synthetic raw material	Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances Class I in 1979, unregistered in Japan, POPs
5. Pentachlorophenol (PCP)	Antiseptic, herbicide, bactericide	Lapsed in 1990, Water-pollutant Agricultural Chemicals, Poisonous and Deleterious Substances Control Law
6. 2,4,5-Trichlorophenoxyacetic acid	Herbicide	Lapsed in 1975, Poisonous and Deleterious Substances Control Law, Food Sanitation Law
7. 2,4-Dichlorophenoxyacetic acid	Herbicide	Registered
8. Amitrole	Herbicide, disperse dye, hardener for resins	Lapsed in 1975, Food Sanitation Law
9. Atrazine	Herbicide	Registered
10. Alachlor	Herbicide	Registered, Marine Pollution Prevention Law
11. Simazine (CAT)	Herbicide	Registered, Water Pollution Control Law, Environmental Quality Standards for Groundwater, Soil Pollution, and Water Pollutants, Waste Disposal and Public Cleaning Law, Waterworks Law
12. Hexachlorocyclohexane, Ethyl parathion	Insecticide,	Hexachlorocyclohexane lapsed and banned sales in 1971, ethyl parathion lapsed in 1972
13. Carbaryl	Insecticide	Registered, Poisonous and Deleterious Substances Control Law, Food Sanitation Law
14. Chlordane	Insecticide	Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances Class I in 1981, lapsed in 1968, Poisonous and Deleterious Substances Control Law, POPs
15. Oxychlordane	Chlordane metabolite
16. trans-Nonachlor	Insecticide	Nonachlor unregistered in Japan, heptachlor lapsed in 1972
17. 1,2-dibromo- 3-chloropropane	Insecticide	Lapsed in 1980
18. DDT	Insecticide	Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances Class I in 1981, lapsed and banned sales in 1971, Food Sanitation Law, POPs
19. DDE and DDD	Insecticide (DDT metabolite)	Unregistered in Japan
20. Kelthane (Dicofol)	Acaricide	Registered, Food Sanitation Law
21. Aldrin	Insecticide	Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances Class I in 1981, lapsed in 1975, Soil-persistent Agricultural Chemicals, Poisonous and Deleterious Substances Control Law, POPs
22. Endrin	Insecticide	Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances Class I in 1981, lapsed in 1975, Crop-persistent Agricultural Chemicals, Poisonous and Deleterious Substances Control Law, Food Sanitation Law, POPs
23. Dieldrin	Insecticide	Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances Class I in 1981, lapsed in 1975, Soil-persistent Agricultural Chemicals, Poisonous and Deleterious Substances Control Law, Food Sanitation Law, Harmful Substance Containing Household Products Control Law, POPs
24. Endosulfan (Benzoepin)	Insecticide	Poisonous and Deleterious Substances Control Law, Water-pollutant Agricultural Chemicals
25. Heptachlor	Insecticide	Law Concerning the Examination and Regulation of Manufacture,etc., of Chemical Substances Class I in 1986, lapsed in 1975, Poisonous and Deleterious Substances Control Law, , POPs
26. Heptachlor epoxide	Heptachlor metabolite
27. Malathion	Insecticide	Registered, Food Sanitation Law
28. Methomyl	Insecticide	Registered, Poisonous and Deleterious Substances Control Law
29. Methoxychlor	Insecticide	Lapsed in 1960
30. Mirex	Insecticide	Unregistered in Japan, POPs
31. Nitrofen	Herbicide	Lapsed in 1982
32. Toxaphene (Camphechlor)	Insecticide	Unregistered in Japan, POPs
33. Tributyltin	Antifouling paints on ships, antiseptic for fishnets	Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substancesre TBTO: Class I, the remaining 13 substances: Class II TB in 1990, Harmful Substance Containing Household Products Control Law
34. Triphenyltin	Antifouling paints on ships, antiseptic for fishnets	Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances Class II in 1990, lapsed in 1990, Harmful Substance Containing Household Products Control Law
35. Trifluralin	Herbicide	Registered
36. Alkyl phenol (from C5 to C9) Nonyl phenol Octyl phenol	Raw material for surface-active agents/decomposition product Raw material for surface-active agents/decomposition product	Marine Pollution Prevention Law
37. Bisphenol A	Raw material for resins	Food Sanitation Law
38. Di-(2-ethylhexyl)phthalate	Plasticizer for plastics	Monitoring substances in water environment
39. Butyl benzyl phthalate	Plasticizer for plastics	Marine Pollution Prevention Law
40. Di-n-butyl phthalate	Plasticizer for plastics	Marine Pollution Prevention Law
41. Dicyclohexyl phthalate	Plasticizer for plastics
42. Diethyl phthalate	Plasticizer for plastics	Marine Pollution Prevention Law
43. Benzo(a)pyrene	(Unintended product)
44. Dichlorophenol	Dye intermediate	Marine Pollution Prevention Law
45. Diethylhexyl adipate	Plasticizer for plastics	Marine Pollution Prevention Law
46. Benzophenone	Synthetic raw materials for medical products, perfume, etc.
47. 4-Nitrotoluene	2,4-dinitrotoluene intermediate	Marine Pollution Prevention Law
48. Octachlorostyrene	(By-product of organic chlorine compound)
49. Aldicarb	Insecticide	Unregistered in Japan
50. Benomyl	Bactericide	Registered
51. Kepone (Chlordecone)	Insecticide	Unregistered in Japan
52. Manzeb (Mancozeb)	Bactericide	Registered
53. Maneb	Bactericide	Registered
54. Metiram	Bactericide	Lapsed in 1975
55. Metribuzin	Herbicide	Registered, Food Sanitation Law
56. Cypermethrin	Insecticide	Registered, Poisonous and Deleterious Substances Control Law, Food Sanitation Law
57. Esfenvalerate	Insecticide	Registered, Poisonous and Deleterious Substances Control Law
58. Fenvalerate	Insecticide	Registered, Poisonous and Deleterious Substances Control Law, Food Sanitation Law
59. Permethrin	Insecticide	Registered, Food Sanitation Law
60. Vinclozololin	Bactericide	Lapsed in 1998
61. Zineb	Bactericide	Registered
62. Ziram	Bactericide	Registered
63. Dipentyl phthalate		Not produced in Japan
64. Dihexyl phthalate		Not produced in Japan
65. Dipropyl phthalate		Not produced in Japan
66. Styrens	Non-reacting substance of styrene-rubber plastic
67. n-Butylbenzene	Synthesis intermediate, for liquid crystal manufacture

NOTE

(1)	Besides the above substances, cadmium, lead, and mercury are also suspected of having endocrine disrupting effects.
(2)	In the environmental investigation column, (2 indicates that the substance has been detected and i indicates that it has not been detected. Substances with no mark have not been investigated.
(3)	The laws described in the restrictions column indicate that the substance is subject to restrictions under such laws.
(4)	"Registered", "lapsed", "unregistered in Japan," "Soil-persistent Agricultural Chemicals," "Crop-persistent Agricultural Chemicals," "Water-pollutant Agricultural Chemicals" are based on the Agricultural Chemicals Regulation Law.
(5)	POPs are residual organic pollutants specified in the "World Action Plan Concerning the Protection of the Marine Environment by Conducting Environmental Protection Activities on Land".