保健・化学物質対策

International Symposium on Environmental Endocrine Disrupters 2002

International Conference Center Hiroshima
November 26-28, 2002

Abstracts

Program and Speakers

Program open to the public

Program for Experts

PROGRAM in abridged edition

LEAFLET

Symposium Outline (Last updated on November 29, 2002)

Organizer : Ministry of the Environment, Government of Japan
Dates : November 26 (Tuesday) to November 28(Thursday), 2002
Venue : International Conference Center Hiroshima
　1-5 Nakajima-cho, Naka-ku, 730-0811 Hiroshima Japan
　Tel: +81-(0)82-242-7777 Fax: +81-(0)82-242-8010
　English and Japanese (Simultaneous interpretation will be provided.)


Objectives :

  1. To share information concerning initiatives taken by various countries of the world for dealing with ED-related issues;
  2. To discuss the direction of future research on endocrine disrupters through international cooperation; and
  3. To to provide an opportunity for an exchange of opinions on chemicals that various stakeholders (e.g. general public, NGOs, technical experts, industry and government) may have.

Programs and Presentation Topics:

November 26 Program open to the public (afternoon only)

13:00-13:30　Opening Remarks

Greetings by the Organizer and Guests

13:30-14:30　Special Lecture

Abstract of Special Lecture [PDF]

The lecture will be given by Osamu Tsutsumi M.D., Professor of Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, who has investigated possible effects of chemicals on child health as is noted as a pioneer of reproductive medicine in Japan.

Speaker
　Heath of fetus, next generation
Osamu Tsutsumi
　University of Tokyo, Japan

14:30-16:00　Initiatives Abroad and in Japan

Abstracts of Initiatives Abroad and in Japan [PDF]

This part provides introductions of the current measures and trends concerning the problem of endocrine disrupters conducted internationally and in Japan.

Current OECD Initiatives and Progress in Endocrine Disrupters Tenting and Assessment
　Herman B. W. M. Koeter, OECD
Global assessment of the state-of-the-science of endocrine disruptors
　Tim Meredith, WHO
Environmental Endocrine Disrupters Assessment: Strategy of the European Commission
　Claudia Roncancio-Pena, European Commission, Belgium
Assay Validation Studies In Progress in the U.S. Endocrine Disrupter Screening Program
　James P. Kariya, EPA, USA
U.S. Interagency Evaluation of in vitro Endocrine Disruptor Testing Methods
　William S. Stokes, ICCVAM, USA
Initiative in the Ministry of the Environment, Government of Japan
　Hironori Hamanaka, Ministry of the Environment, Government of Japan

16:15-18:00　Panel Discussion - Environmental risk communication -

Abstracts of Panel Discussion - Environmental risk communication - [PDF]

It is an opportunity to deeply understand the problem of endocrine disrupters through the exchange of their opinions and the discussion of how to communicate together "the Risks of Chemicals as endocrine disrupters", with a focus on environmental education for children, by the panelists who participate from various backgrounds. (e.g. research institutes, NGO, educational institutions, industry and government)

Panelists:
　Taisen Iguchi, Okazaki National Research Institutes, Japan
　Kimihiro Iwamoto, Mitsui Chemicals, Inc., Japan
　Yuko Sakita, Journalist and Environmental Counselor, Japan
　Keiko Endo, Yamamoto Elementary School, City of Hiroshima, Japan
　Kazuhiko Adachi, Ministry of the Environment, Japan
Moderator:
　Goro Koide, NHK and Otsuma Women's University, Japan

November 27　Program for Experts

9:00-11:45　Session 1 - Effect on Immune System

Abstracts of Session 1 - Effect on Immune System [PDF]

Among the chemicals which are suspected of disrupting the endocrine system, many of them are also reported to adversely affect the immune system. The objective of this session is to present and discuss the effects of these chemicals on the immune system and their underlying mechanisms.

Chairpersons:
　Keiko Nohara, National Institute for Environmental Studies, Japan
　Henk Van Loveren, National Institute of Public Health and the Environment, Netherlands

The immune-neuro-endocrine network: the interphase between environmental and internal signals
　Hugo O. Besedovsky, Philipps Marburg University, Germany
Immunological Analysis of The Low Dose Exposure Syndromes
　Kou Sakabe, The Kitasato Institute, Japan
Health Effects of PCBs: The Immune System
　Henk Van Loveren, National Institute of Public Health and the Environment, Netherlands
Cellular targets of TCDD-induced immunotoxicity
　Keiko Nohara, National Institute for Environmental Studies, Japan
Molecular Analysis of the Inhibition of Chemokine Gene Expression by Xenoestrogens
　Hidekuni Inadera, University of Tokyo, Japan

13:00-15:00　Session 2 - Frogs

Abstracts of Session 2 - Frogs [PDF]

Frogs have attracted people ranging from investigators to the public for their close habitation to us and are useful as model animals in a variety of studies in life science including developmental biology, ecology, and physiology. Recent studies have demonstrated that some of chemicals suspected to be the endocrine disrupters which influence on the process of metamorphosis via thyroid hormone. The session provides the current status of studies on the mechanism of action of thyroid hormone in tadpole metamorphosis and discussions on the possible mechanism by which endocrine disrupters may influence the process of metamorphosis.

Chairperson：
　Katsutoshi Yoshizato, Hiroshima University, Japan

Anuran metamorphosis - an attractive biological process to study the mechanism of the larval to adult tissue remodeling and to detect thyroid disruptors -
　Katsutoshi Yoshizato, Hiroshima University, Japan
Duel function of thyroid hormone receptor during amphibian development
　Yun-Bo Shi, National Institutes of Health, USA
Molecular Mechanism of Muscle Cell Death by Thyroid Hormone in Amphibian Tadpole Tail
　Yoshio Yaoita, Hiroshima University, Japan
Design and testing of thyroid hormone responsive reporter gene constructs for generating transgenic Xenopus models for detecting endocrine disrupters.
　Barbara Demeneix, Museum National d'Histoire Naturelle, France
Impact of polychlorinated biphenyls on amphibian development, behavior and endocrine physiology
　Robert J. Denver, University of Michigan, USA

15:15-16:45　Session 3 - Thyroid Hormone

Abstracts of Session 3 - Thyroid Hormone [PDF]

Thyroid hormone plays an important role in growth and metabolism of vertebrates including mammals. It has been reported that the chemicals, which are suspected of disrupting the endocrine system, interfere with secretion and action of thyroid hormone. This session provides current scientific findings on the mechanism of these chemicals in relation with thyroid hormone action.

Chairperson:
　Hisao Seo, Nagoya University of Nagoya, Japan

Endocrine disrupters and thyroid function
　Hisao Seo, Nagoya University of Nagoya, Japan
Steroid Receptor Coactivator, SRC-3, and Prostate Cancer
　Ming-Jer Tsai, Baylor College of Medicine, USA
Thyroid hormones: multiple roles through multiple receptors
　Jacques Samarut, Ecole Normale Superieure de Lyon, France
Thyroid Hormone Receptor Mutations and the Development of Thyroid Cancer
　Sheue-yann Cheng, National Cancer Institute, USA

17:00-18:00　Discussion - Frogs / Thyroid Hormone

This discussion provides an opportunity for investigators of frogs and mammals to exchange and share their opinions and learning with the thyroid hormone as its common theme.

Chairpersons:
　Katsutoshi Yoshizato, Hiroshima University, Japan
　Taisen Iguchi , Okazaki National Research Institutes, Japan

Panelists
　Robert J. Denver, University of Michigan, USA
　Barbara Demeneix, Museum National d'Histoire Naturelle, France
　Yun-Bo Shi, National Institutes of Health, USA
　Jacques Samarut, Ecole Normale Superieure de Lyon, France
　Ming-Jer Tsai, Baylor College of Medicine, USA
　Sheue-yann Cheng, National Cancer Institute, USA

19:30-21:30　Night Session - Sexual Differentiation

Abstracts of Night Session - Sexual Differentiation> [PDF]

Sex difference in several brain structures is established independent of genetic sex during a limited period of ontogeny under the effects of sex hormones and culminates in sex-specific regulation of reproductive endocrinology and emotional behavior. In this session, recent results will be discussed in an attempt to understand the action of chemicals that disrupt the process of the brain sex differentiation.

Chairperson:
　Yasuo Sakuma, Nippon Medical School, Japan

Estrogen Receptor and Brain Sex Differentiation
　Yasuo Sakuma, Nippon Medical School, Japan
Sexual differentiation of sexual behavior
　James G. Pfaus, Concordia University, Canada
Hypothalamic Development and Sexual Differentiation
　Stuart A. Tobet, UMASS Medical School, USA
Sex determination and gonadal sex differentiation in fish
　Yoshitaka Nagahama, Okazaki National Research Institutes, Japan

November 28 Program for Experts

9:30-11:30　Session 4 - Exposure Assessment / Risk Assessment

Abstracts of Session 4 - Exposure Assessment / Risk Assessment [PDF]

This discussion provides recent topics concerning a risk assessment or an exposure assessment such as integrated effects of multiple chemicals.

Chairperson:
　Masatoshi Morita, National Institute for Environmental Studies, Japan

Recent Evidence for Low Dose Effects of Bisphenol A
　Frederik S. vom Saal, University of Missouri-Columbia, USA
Newly arising endocrine disruptors: UV filters in cosmetics
　Margret Schlumpf, University of Zurich, Switzerland
Endocrine disruption - the trouble with mixtures
　Andreas Kortenkamp, University of London, UK
Environmental Endocrine Disrupters Assessment: Strategy of the European Commission
　Claudia Roncancio-Pena, European Commission, Belgium

12:45-15:15　Session 5 - Children's Health

Abstracts of Session 5 - Children's Health [PDF]

Offers recent scientific findings about influences of environmental chemicals on the health of children or fetuses, which are generally more susceptible to such influences than adults. This session also deals with current epidemiological studies on male reproductive health.

Chairpersons:
　Jorma Toppari, University of Turku, Finland
　Teruaki Iwamoto, St. Marianna University, School of Medicine, Japan

Regional differences and temporal trends in semen quality
　Niels Jorgensen, Copenhagen University Hospital, Denmark
Current Status of Semen Quality in Japan
　Teruaki Iwamoto, St. Marianna University, School of Medicine, Japan
Regional and temporal trends in the prevalence of cryptorchidism and hypospadias
　Jorma Toppari, University of Turku, Finland
Persistent Organic Pollutants (POPs) in Human Breast Milk Collected from Asian Developing Countries: Risk Assessment for Infants
　Shinsuke Tanabe, Ehime University, Japan
New Ways to Investigate Contamination and Human Health
　Elizabeth A. Guillette, University of Florida, USA
Fetal exposure to endocrine disruptors during human pregnancy in Japan
　Fumiki Hirahara, Yokohama City University, Japan
　Kenji Kurosawa, Kanagawa Children's Medical Center, Japan

15:30-17:00　Discussion - Children's Health / Risk Assessment

Much attention is currently focused on the health effects on children by multiple chemicals. In this session, specialists will discuss about risk assessment based on the children and fetuses.

Chairperson:
　Chisato Mori, Chiba University, Japan

Panelists
　Jorma Toppari, University of Turku, Finland
　Fumiki Hirahara, Yokohama City University, Japan
　Masatoshi Morita, National Institute for Environmental Studies, Japan
　Frederik S. vom Saal, University of Missouri-Columbia, USA

Commentators:
　John P. Myers, United Nations Foundation, USA
　Richard A. Becker, American Chemistry Council, USA

Closing Remarks