MEDAKA
Development of Test Methods and Suitability of Medaka as Test Organism
for Detection of Endocrine Disrupting Chemicals
February 2003
Ministry of the Environment, Japan
Chemicals Evaluation and Research Institute, Japan
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| ALL of Docments for JAPANESE OS Users [PDF 3383KB] ALL of Docments for ENGLISH OS Users [PDF 3181KB] |
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| JAPANESE OS users | ENGLISH OS users | ||||
| Cover | JP | EN | |||
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| Contents | JP | EN | |||
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| Preface | JP | EN | |||
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| Summary | JP | EN | |||
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| Chapter 1: | Suitability of Medaka fish as Test Organism and New Medaka Strains | JP | EN | ||
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| Chapter 2: | Receptor Binding Assay and Reporter Gene Assay of Medaka | JP | EN | ||
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| Chapter 3: | Medaka Screening and Definitive Test for Endocrine Disrupting Chemicals | ||||
| Part 1: | Validation with Reference Chemicals | JP | EN | ||
| Part 2: | Hazard Assessment of Tributyltin (TBT) and 4-Nonylphenol (NP) | JP | EN | ||
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| Chapter4: | Genetic Approaches to Understanding the Basic Mechanisms of Endocrine Disruptor Actions on sex Determination/Differentiation in the Medaka, Oryzias latipes | JP | EN | ||
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| Further Works | JP | EN | |||
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| Appendix I | I | The medaka(Oryzias Latipes) Partial Life-Cycle Test Guideline | JP | EN | |
| II | The medaka(Oryzias Latipes) Full Life-Cycle Test Guideline | JP | EN | ||
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| Appendix II | I | Effect of ethinylestradiol on the reproduction and induction of vtellogenin and tests-ova in Medaka(Oryzias Latipes) | JP | EN | |
| II | Life-cycle toxicity of 4-nonylphenol to Medaka (Oryzias Latipes) | JP | EN | ||
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| Appendix III | Other information regarding Medaka studies | JP | EN | ||
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| Links | Atlas of Medaka Gonadal Histology http://www.nies.go.jp/edc/edcdb/index_j.html Medakafish Home Page -Nagoya University http://biol1.bio.nagoya-u.ac.jp:8000/ Medaka ToxiNet -Kyusyu University http://medaka.fish.agr.kyushu-u.ac.jp/ Medaka Genome Database http://mbase.bioweb.ne.jp/~dclust/medaka_top.html Chemicals Evaluation and Research Institute, Japan http://www.cerij.or.jp/ceri_en/index_e4.shtml National Institute for Environmental Studies, Japan (NIES) http://www.nies.go.jp/ |
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