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環境省保健・化学物質対策科学的知見の充実及び環境リスク評価の推進化学物質の内分泌かく乱作用に関するホームページ資料集・リンク専門家向けデータベース:メダカアトラス トップ >2.Normal Development and Gonadal Histology in Medaka (1)

「資料集・リンク」

資料集・リンク
専門家向けデータベース

「専門家向けデータベース」

Atlas of Medaka Gonadal Histology

by MOE and Chemicals Evaluation and Research Institute, Japan (CERI)

Atlas of Gonadal Histopathology in Medaka Exposed to Endocrine Disruptors

Effect of estrogen exposure

Testis-ova

Testis-ova from a fish exposed to 224 µg/L of 4-tert-pentylphenol from fertilized egg to 61-d posthatch (Bouin, H&E).
O: oocyte, Sc: spermatocyte, Sz: spermatozoa.
Oocytes appear in clusters within the testicular tissue. Numerous spermatocytes and spermatozoa are still present in a compacted mass in this section.

Testis-ova

Progressed testis-ova

Testis-ova from a fish exposed to 931 µg/L of 4-tert-pentylphenol from fertilized egg to 61-d posthatch (Bouin, H&E).
O: oocyte, Sc: spermatocyte, Sz: spermatozoa.
A more progressed testis-ova. Almost the entire area is composed of oocytes, accompanying small testicular tissues interspersed with a few spermatocytes.

Progressed testis-ova

Testis-ova & connective tissue

Testis-ova from a fish exposed to 931 µg/L of 4-tert-pentylphenol from fertilized egg to 61-d posthatch (Bouin, H&E).
O: oocyte, Ct: connective tissues, Sz: spermatozoa.
Connective tissues develop well in a testis-ova specimen with a few spermatozoa.

Testis-ova & connective tissue

Regressed ovary

Ovary from an adult female fish exposed to 488 ng/L of ethinylestradiol for 3 weeks (Bouin, H&E,).
Po: previtellogenic oocyte
Many previtellogenic oocytes exist in this specimen, suggesting regressed ovary.

Regressed ovary